| Title | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin |
| Authors | Liu, Yiqiong Sun, Yunong Zhao, Xiaoyan Kim, Ji-Young Luo, Lu Wang, Qian Meng, Xiaolu Li, Yonghui Sui, Nan Chen, Zhou-Feng Pan, Chuxiong Li, Liang Zhang, Yan |
| Affiliation | Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100005, Peoples R China Washington Univ, Sch Med, Dept Anesthesiol, Dept Psychiat,Dept Dev Biol,Ctr Study Itch, St Louis, MO 63110 USA Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China Beijing Inst Brain Disorders, Beijing 100069, Peoples R China Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China Hendrix Coll, Conway, AR 72032 USA PKU IDG McGovem Inst Brain Res, Beijing 100871, Peoples R China |
| Keywords | 5-HT Aggression Social isolation Dopamine Lmx1b |
| Issue Date | 2019 |
| Publisher | NEUROSCIENCE BULLETIN |
| Abstract | Isolation rearing (IR) enhances aggressive behavior, and the central serotonin (5-hydroxytryptamine, 5-HT) system has been linked to IR-induced aggression. However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2(-/-) and Lmx1b(-/-), we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1b(-/-) mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1b(-/-) mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1b(-/-) mice. Our results link the serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. |
| URI | http://hdl.handle.net/20.500.11897/544897 |
| ISSN | 1673-7067 |
| DOI | 10.1007/s12264-019-00373-w |
| Indexed | SCI(E) SSCI(E) EI |
| Appears in Collections: | 生命科学学院 膜生物学国家重点实验室 心理与认知科学学院 行为与心理健康北京市重点实验室 |
