| Title | Glutathione S-Transferase Pi 1 (GSTP1) Gene 313 A/G (rs1695) polymorphism is associated with the risk of urinary bladder cancer: Evidence from a systematic review and meta-analysis based on 34 case-control studies |
| Authors | Song, Yuxuan Chen, Jingyi Liu, Kang Zhou, Kechong Lu, Yi Wang, Xiao Yang, Yongjiao Liu, Xiaoqiang |
| Affiliation | Tianjin Med Univ, Gen Hosp, Dept Urol, 154 Anshan Rd, Tianjin 300052, Peoples R China Peking Univ, Peoples Hosp, Dept Cent Lab, Beijing 100044, Peoples R China Peking Univ, Peoples Hosp, Inst Clin Mol Biol, Beijing 100044, Peoples R China Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China |
| Keywords | Urinary bladder cancer GSTP1 Polymorphism Systematic review Meta-analysis |
| Issue Date | 2019 |
| Publisher | GENE |
| Abstract | Background: Glutathione S-transferases (GSTs) contain a series of critical enzymes regulating proliferation or apoptosis in the tumor microenvironment. Data from publications about the correlation between Glutathione S-transferase Pi 1 (GSTP1) gene 313 A/G (rs1695) polymorphism and bladder caner (BCa) remained controversial. To explore the exact correlation between this polymorphism and the development of BCa, we carried out this study. Materials and methods: All relevant publications from Pubmed, Web of Science, Cochrane Library, PMC, Embase and Wanfang databases (from building to March 30th, 2019) were retrieved. This meta-analysis was carried out by utilizing STATA software. Results: 34 case-control studies with 15,704 participants recruiting 7236 BCa patients and 8468 healthy controls were ultimately analyzed in our study. The pooling results indicated that GSTP1 gene 313 A/G (rs1695) polymorphism was obviously related to BCa (GG vs AA: OR = 1.33, 95%CI = 1.04-1.69). Similar results were found in the association between this polymorphism and transitional cell carcinoma (TCC) risk (GG vs AA: OR = 1.95, 95%CI = 1.18-3.23). Furthermore, we revealed an increased association between the GG genotype and BCa in Asians (GG vs AA: OR = 2.04, 95%CI = 1.09-3.79), while no correlation was revealed in Caucasians. As to different tumor grades or stages, this polymorphism was considered to elevate low grade BCa development and null results were uncovered with high grade BCa. Conclusion: This study indicated that GSTP1 gene 313 A/G (rs1695) polymorphism increased the susceptibility to BCa, particularly to TCC. In addition, this study found that this polymorphism was obviously related to elevated BCa risk in Asian population and also increased low grade BCa risk. Results based on the five genetic models indicated that GSTP1 G-allele might be the susceptibility gene and GG genotype might be the susceptibility genotype. |
| URI | http://hdl.handle.net/20.500.11897/544626 |
| ISSN | 0378-1119 |
| DOI | 10.1016/j.gene.2019.144077 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
