| Title | Type-II Pauson-Khand reaction of 1,8-enyne in the attempt of building 7/5 ring of (-)-caribenol A and DFT understanding |
| Authors | Wang, Yang Liu, Kang Yu, Zhi-Xiang Jia, Yanxing |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China Peking Univ, Coll Chem, Minist Educ, BNLMS,Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China |
| Keywords | Terpenoids Type-II Pauson-Khand reaction Synthetic study Computational study |
| Issue Date | 2019 |
| Publisher | TETRAHEDRON LETTERS |
| Abstract | An attempt to access the fused 7/5 ring of the highly biologically active terpenoid caribenol A by employing intramolecular Pauson-Khand reaction of 1,8-enyne gave bridged 8-5 ring, the type-11 Pauson-Khand reaction product. DFT study has been carried out to elucidate this unexpected regioselectivity. (C) 2019 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/543741 |
| ISSN | 0040-4039 |
| DOI | 10.1016/j.tetlet.2019.151001 |
| Indexed | IC SCI(E) EI |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
