| Title | Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins |
| Authors | Ai, Lingsheng Wang, Weijin Wei, Jialiang Li, Qing Song, Song Jiao, Ning |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| Keywords | halogenation alcohols dimethyl sulfoxide halohydrins oxidation |
| Issue Date | 2019 |
| Publisher | SYNLETT |
| Abstract | beta-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective -halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of -halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical. |
| URI | http://hdl.handle.net/20.500.11897/543553 |
| ISSN | 0936-5214 |
| DOI | 10.1055/s-0037-1610385 |
| Indexed | CCR IC SCI(E) EI |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
