| Title | Copper-catalyzed ring-opening C(sp(3))-N coupling of cycloketone oxime esters: access to 1 degrees, 2 degrees and 3 degrees alkyl amines |
| Authors | Tian, Li Gao, Shuangqiu Wang, Rui Li, Yang Tang, Chunlin Shi, Lili Fu, Junkai |
| Affiliation | Northeast Normal Univ, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Dept Chem, Changchun 130024, Jilin, Peoples R China Peking Univ, Key Lab Chem Genom, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China |
| Issue Date | 2019 |
| Publisher | CHEMICAL COMMUNICATIONS |
| Abstract | A novel copper-catalyzed C(sp(3))-N coupling of cycloketone oxime esters with nitrogen nucleophiles has been realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine could be employed in this protocol to produce a variety of 1 degrees, 2 degrees and 3 degrees alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proven to be versatile synthetic building blocks in a variety of chemical transformations. |
| URI | http://hdl.handle.net/20.500.11897/543533 |
| ISSN | 1359-7345 |
| DOI | 10.1039/c9cc02030f |
| Indexed | CCR IC SCI(E) EI |
| Appears in Collections: | 化学生物学与生物技术学院 |
