| Title | Pd-Catalyzed Decarboxylative Allylation for Stereoselective Syntheses of Allylic Alcohols bearing a Quaternary Carbon Center |
| Authors | Shi, Linlin He, Yingdong Gong, Jianxian Yang, Zhen |
| Affiliation | Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Genom,Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China Peking Univ, Peking Tsing Hua Ctr Life Sci, Beijing 100871, Peoples R China |
| Issue Date | 2019 |
| Publisher | ASIAN JOURNAL OF ORGANIC CHEMISTRY |
| Abstract | Olefins play a vital role in the fields of bioscience, medicine, and chemistry. Stereo-defined olefins are important resource in both chemical laboratory and industry. Using a palladium-catalyzed decarboxylative transformation of vinyl cyclic carbonates, we have developed an efficient and reliable method for the direct construction of highly substituted olefins with the concomitant formation of a new Csp(3)-Csp(3) bond. The desired olefins could be generated in reasonable yields with good stereoselectivities, in contrast to the existing methods, which are usually non-stereoselective. The palladium-catalyzed decarboxylative transformation will undoubtedly provide new synthetic routes for the formation of multi-substituted allylic scaffolds. |
| URI | http://hdl.handle.net/20.500.11897/543530 |
| ISSN | 2193-5807 |
| DOI | 10.1002/ajoc.201900208 |
| Indexed | CCR IC SCI(E) EI |
| Appears in Collections: | 深圳研究生院待认领 化学与分子工程学院 生物有机与分子工程教育部重点实验室 生命科学学院 |
