| Title | Noninvasive rapid bacteria-killing and acceleration of wound healing through photothermal/photodynamic/copper ion synergistic action of a hybrid hydrogel |
| Authors | Li, Mu Liu, Xiangmei Tan, Lei Cui, Zhenduo Yang, Xianjin Li, Zhaoyang Zheng, Yufeng Yeung, Kelvin Wai Kwok Chu, Paul K. Wu, Shuilin |
| Affiliation | Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Min.-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China State Key Laboratory for Turbulence, Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, 999077, Hong Kong Department of Physics and Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, 999077, Hong Kong |
| Issue Date | 2018 |
| Publisher | Biomaterials Science |
| Citation | Biomaterials Science. 2018, 6(8), 2110-2121. |
| Abstract | Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration. © 2018 The Royal Society of Chemistry. |
| URI | http://hdl.handle.net/20.500.11897/530772 |
| ISSN | 20474830 |
| DOI | 10.1039/c8bm00499d |
| Indexed | EI |
| Appears in Collections: | 工学院 |
