| Title | An overview of graphene-based hydroxyapatite composites for orthopedic applications |
| Authors | Li, Ming Xiong, Pan Yan, Feng Li, Sijie Ren, Changhong Yin, Zhichen Li, Ang Li, Huafang Ji, Xunming Zheng, Yufeng Cheng, Yan |
| Affiliation | Capital Med Univ, China Amer Inst Neurosci, Xuanwu Hosp, Beijing 100053, Peoples R China. Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China. Capital Med Univ, Beijing Key Lab Hypoxia Conditioning Translat Med, Xuanwu Hosp, Beijing 100053, Peoples R China. Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China. Columbia Univ, Dept Biomed Engn, New York, NY 10032 USA. Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Musculoskeletal Res Lab, Hong Kong, Hong Kong, Peoples R China. |
| Keywords | Graphene Hydroxyapatite Composites Bone tissue Biomedical devices MESENCHYMAL STEM-CELLS SIMULATED BODY-FLUID BETA-TRICALCIUM PHOSPHATE WALLED CARBON NANOTUBES IN-VITRO MECHANICAL-PROPERTIES BIOMEDICAL APPLICATIONS OSTEOGENIC DIFFERENTIATION NANO-HYDROXYAPATITE BIOMIMETIC MINERALIZATION |
| Issue Date | 2018 |
| Publisher | BIOACTIVE MATERIALS |
| Citation | BIOACTIVE MATERIALS. 2018, 3(1), 1-18. |
| Abstract | Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds. The last few years witnessed increasing numbers of studies on the preparation, mechanical and biological evaluations of these novel materials. Herein, various preparation techniques, mechanical behaviors and toughen mechanism, the in vitro/in vivo biocompatible analysis, antibacterial properties of the graphene-based HA composites are presented in this review. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. |
| URI | http://hdl.handle.net/20.500.11897/528308 |
| ISSN | 2452-199X |
| DOI | 10.1016/j.bioactmat.2018.01.001 |
| Indexed | PubMed ESCI |
| Appears in Collections: | 前沿交叉学科研究院 |
