| Title | [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiotherapy by PET/CT |
| Authors | Sun, Lu Zhou, Kedi Wang, Weijun Zhang, Xiaojun Ju, Zhongjian Qu, Baolin Zhang, Zhizhong Wang, Jinyuan Ling, Zhipei Yu, Xinguang Zhang, Jinming Pan, Longsheng |
| Affiliation | Peoples Liberat Army Gen Hosp, Dept Neurosurg, 28 Fuxing Rd, Beijing, Peoples R China. Peking Univ, Coll Engn, Dept Biomed Engn, 5 Yiheyuan Rd, Beijing, Peoples R China. Peoples Liberat Army Gen Hosp, Dept Nucl Med, 28 Fuxing Rd, Beijing, Peoples R China. Peoples Liberat Army Gen Hosp, Dept Radiat Oncol, 28 Fuxing Rd, Beijing, Peoples R China. Peoples Liberat Army Gen Hosp, Dept Neurosurg, 28 Fuxing Rd, Beijing, Peoples R China. Zhang, JM (reprint author), Peoples Liberat Army Gen Hosp, Dept Nucl Med, 28 Fuxing Rd, Beijing, Peoples R China. |
| Keywords | BRAIN METASTASES IN-VIVO CELL-DEATH THERAPY CANCER RADIOSURGERY MANAGEMENT TRIAL ML-10 |
| Issue Date | 2018 |
| Publisher | CONTRAST MEDIA & MOLECULAR IMAGING |
| Citation | CONTRAST MEDIA & MOLECULAR IMAGING. 2018. |
| Abstract | [18F]ML-10 is a novel apoptosis radiotracer for positron emission tomography (PET). We assess the apoptosis response of intracranial tumor early after CyberKnife (CK) treatment by [18F]ML-10 PETimaging. 29 human subjects (30 lesions), diagnosed with intracranial tumors, underwent CK treatment at 14-24 Gy in 1-3 fractions, had [18F]ML-10 positron emission tomography/computed tomography (PET/CT) before (pre-CK) and 48 hours after (post-CK) CK treatment. Magnetic resonance imaging (MRI) scans were taken before and 8 weeks after CK treatment. Voxel-based analysis was used for the imaging analysis. Heterogeneous changes of apoptosis in tumors before and after treatment were observed on voxel-based analysis of PETimages. A positive correlation was observed between the change in radioactivity (X) and subsequent tumor volume (Y) (r = 0.862, p < 0.05), with a regression equation of Y. 1.018* X 0.016. Malignant tumors tend to be more sensitive to CK treatment, but the treatment outcome is not affected by pre-CK apoptotic status of tumor cells; [18F]ML-10 PET imaging could be taken as an assessment 48 h after CK treatment. |
| URI | http://hdl.handle.net/20.500.11897/524936 |
| ISSN | 1555-4309 |
| DOI | 10.1155/2018/9365174 |
| Indexed | SCI(E) |
| Appears in Collections: | 工学院 |
