| Title | Expression of PD-1 on CD4(+) Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer |
| Authors | Zhao, Yan-Jie Zhang, Jian Shi, Feng Hu, Zhi-Ping Wu, Jiang-Ping Wu, Guang-Jiang Wang, Rui-Bin Zhou, Quan Chang, Hong Li, Ying-Nan Song, Qing-Kun |
| Affiliation | Capital Med Univ, Beijing Shijitan Hosp, Dept Med Oncol, Beijing 100038, Peoples R China. Capital Med Univ, Beijing Chaoyang Hosp, Dept Emergency, Beijing 100020, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Pathol, Beijing 100038, Peoples R China. Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100021, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Canc Res, Beijing 100038, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Infect Control, Beijing 100038, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Emergency, Beijing 100038, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Gastroenterol, Beijing 100853, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Sci & Technol, Beijing 100038, Peoples R China. Beijing Key Lab Canc Therapeut Vaccine, Beijing, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Gastroenterol, Beijing 100853, Peoples R China. Song, QK (reprint author), Capital Med Univ, Beijing Shijitan Hosp, Dept Sci & Technol, Beijing 100038, Peoples R China. Song, QK (reprint author), Beijing Key Lab Canc Therapeut Vaccine, Beijing, Peoples R China. |
| Keywords | T-CELLS KI67 LEUKEMIA PROGNOSIS CARCINOMA SURVIVAL ANTIGEN ROLES STAGE TILS |
| Issue Date | 2018 |
| Publisher | JOURNAL OF IMMUNOLOGY RESEARCH |
| Citation | JOURNAL OF IMMUNOLOGY RESEARCH. 2018. |
| Abstract | Objective. This study aimed to investigate the correlation of CD4(+)/PD-1(+) or CD4(+)/PD-1(-) tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods. A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed cell death protein 1 (PD-1), CK7, CK20, E-cadherin, or Ki-67 was detected by immunohistochemistry. The associations between CD4(+)/PD-1(+) or CD4(+)/PD-1(-) tumor-infiltrating lymphocytes and pathological characteristics were evaluated. Results. Elderly patients intended to have a lower level of CD4(+)/PD-1(-) tumorinfiltrating lymphocytes (p <0.05). Patients with positive E-cadherin expression had higher median cell counts of CD4(+)/PD-1 tumor-infiltrating lymphocytes than patients with negative E-cadherin expression (30/HPF versus 10/HPF, p < 0.05). Counts of CD4(+)/PD-1(+) tumor-infiltrating lymphocytes had a significant correlation with Ki-67 index that the correlation coefficient was 0.29 (p = 0.001). Positive CK20 expression was related to a higher level of CD4(+)/PD-1(-) tumor-infiltrating lymphocytes than negative CK20 expression (73/HPF versus 30/HPF, p < 0.05). Conclusion. CDe/PD-1(+) or CD4(+)/PD-1(-) tumor-infiltrating lymphocytes showed diverse association with pathological features of breast cancer. CD4(+)/PD-1(+) tumor-infiltrating lymphocytes had a significant relationship with Ki-67 expression whereas CD4(+)/PD-1(-) tumor-infiltrating lymphocytes had a significant relationship with E-cadherin expression. Further studies are warranted to explore the immunomodulatory effects of phenotypes of CD4(+) T cell subsets in breast cancer. |
| URI | http://hdl.handle.net/20.500.11897/524905 |
| ISSN | 2314-8861 |
| DOI | 10.1155/2018/5690258 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
