| Title | Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes |
| Authors | Huang, Xiuting Gong, Siqian Ma, Yumin Cai, Xiaoling Zhou, Lingli Luo, Yingying Li, Meng Liu, Wei Zhang, Simin Zhang, Xiuying Ren, Qian Zhu, Yu Zhou, Xianghai Zhang, Rui Chen, Ling Gao, Xueying Zhang, Fang Wang, Yanai Han, Xueyao Ji, Linong |
| Affiliation | Peking Univ, Diabet Ctr, Dept Endocrinol & Metab, Peoples Hosp, Beijing, Peoples R China. |
| Keywords | HEPATOCYTE NUCLEAR FACTOR-1-ALPHA HEPATITIS-C VIRUS HEPATOCELLULAR-CARCINOMA LIPID-METABOLISM TRANSCRIPTION FACTORS LIVER ADENOMATOSIS EMERGING ROLE ALPHA-GENE MICRORNA-122 YOUNG |
| Issue Date | 2018 |
| Publisher | JOURNAL OF DIABETES RESEARCH |
| Citation | JOURNAL OF DIABETES RESEARCH. 2018. |
| Abstract | miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1 : 2) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), P = 0.02] and healthy controls [0.249 (0.049, 1.234), P = 0.019]. The area under the curve of the receiver operating characteristic curve for miR-122 to discriminate HNF1A-DM and T2DM was 0.687 (95% CI: 0.52-0.86, P=0.07). There was no difference in serum miR-122 among HNF1A-DM, GCK-DM, MDM, and T1DM patients. Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients. |
| URI | http://hdl.handle.net/20.500.11897/524862 |
| ISSN | 2314-6745 |
| DOI | 10.1155/2018/7842064 |
| Indexed | SCI(E) PubMed Medline |
| Appears in Collections: | 人民医院 |
