| Title | A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk |
| Authors | Xiao, Qin Chen, Lianzhou Luo, Haiqing Li, Hongmei Kong, Qingming Jiao, Fei Pang, Shifeng Zhang, Ming Lan, Feifei Fan, Wenguo Luo, Hui Tao, Tao Zhu, Xiao |
| Affiliation | Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan Sci Res Ctr, Dongguan, Peoples R China. Peking Univ, Shenzhen Hosp, Dept Blood Transfus, Shenzhen, Peoples R China. Sun Yat Sen Univ, Digest Syst Tumor Tissue Bank, Ctr Surg Lab, Guangzhou, Guangdong, Peoples R China. Guangdong Med Univ, Affiliated Hosp, Ctr Canc, Zhanjiang, Peoples R China. Guangdong Med Univ, Dept Pathol, Dongguan, Peoples R China. Zhejiang Acad Med Sci, Immun & Biochem Res Lab, Hangzhou, Zhejiang, Peoples R China. Binzhou Med Univ, Dept Biochem & Mol Biol, Yantai, Peoples R China. Zibo Cent Hosp, Dept Gastroenterol, Zibo, Peoples R China. Guangdong Women & Children Hosp, Forens Identificat Inst, Guangzhou, Guangdong, Peoples R China. Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangzhou, Guangdong, Peoples R China. Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan Sci Res Ctr, Dongguan, Peoples R China. Tao, T (reprint author), Zibo Cent Hosp, Dept Gastroenterol, Zibo, Peoples R China. |
| Keywords | CHD5 Gene haplotype Hepatocellular carcinoma Alcohol intake Risk TUMOR-SUPPRESSOR GENE CELL-GROWTH CANCER ASSOCIATION ONCOGENE SMOKING 1P36 |
| Issue Date | 2018 |
| Publisher | BMC CANCER |
| Citation | BMC CANCER. 2018, 18. |
| Abstract | Background: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC). Methods: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. Results: We discovered a rare variant (haplotype AG) in CHD5 (rs12564469-rs9434711) that was markedly associated with the risk of HCC in a Chinese population. A logistical regression model and permutation test confirmed the association. Indeed, the association quality increased in a gene dose-dependent manner as the number of samples increased. In the stratified analysis, this haplotype risk effect was statistically significant in a subgroup of alcohol drinkers. The false-positive report probability and multifactor dimensionality reduction further supported the finding. Conclusions: Our results suggest that the rare CHD5 gene haplotype and alcohol intake contribute to the risk of HCC. Our findings can be valuable to researchers of cancer precision medicine looking to improve diagnosis and treatment of HCC. |
| URI | http://hdl.handle.net/20.500.11897/523656 |
| ISSN | 1471-2407 |
| DOI | 10.1186/s12885-018-4551-y |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
