| Title | Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls |
| Authors | Deng, Yongqiong Wang, Hong Zhou, Jiyuan Mou, Yunzhu Wang, Guiqiang Xiong, Xia |
| Affiliation | Southwest Med Univ, Dept Dermatol & STD, Affiliated Hosp, 25 Taiping St, Luzhou, Sichuan, Peoples R China. Peking Univ, Hosp 1, Dept Infect Dis, 8 Xishiku St, Beijing, Peoples R China. Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen Peking Univ, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China. North Sichuan Med Coll, Affiliated Hosp, Dept Dermatol & STD, Nanchong, Sichuan, Peoples R China. Southwest Med Univ, Dept Dermatol & STD, Affiliated Hosp, 25 Taiping St, Luzhou, Sichuan, Peoples R China. Wang, GQ (reprint author), Peking Univ, Hosp 1, Dept Infect Dis, 8 Xishiku St, Beijing, Peoples R China. |
| Keywords | acne vulgaris gut microbiota bacterial diversity INFLAMMATORY-BOWEL-DISEASE DIET DYSBIOSIS METABOLISM DIVERSITY BACTERIA IMMUNITY MICE AXIS |
| Issue Date | 2018 |
| Publisher | ACTA DERMATO-VENEREOLOGICA |
| Citation | ACTA DERMATO-VENEREOLOGICA. 2018, 98(8), 783-790. |
| Abstract | Acne vulgaris has been postulated to have a gastrointestinal mechanism; however, little is known about gut microbiota dysfunction in this condition. The aim of this cross-sectional study was to investigate whether the gut microbiota is altered in acne. Faecal bacterial diversity was analysed in 43 patients with acne and 43 controls, using hypervariable tag sequencing of the V3-V4 region of the 16S rDNA gene. Distinct differences were found in microbial diversity between patients with acne and controls (Shannon diversity index (p = 0.009) and Simpson diversity index (p = 0.01)). At the phylum level, the abundance of Firmicutes was lower in the patient group, but that of Bacteroidiain was higher. The most significantly depleted taxa in acne were Clostridia, Clostridiales, Lachnospiraceae and Ruminococcaceae genera, which are potentially beneficial. In conclusion, patients with acne vulgaris have gut microbial dysbiosis; further study is needed to understand its role in the pathogenesis of acne. |
| URI | http://hdl.handle.net/20.500.11897/522909 |
| ISSN | 0001-5555 |
| DOI | 10.2340/00015555-2968 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 化学生物学与生物技术学院 |
