| Title | Autophagy-deficient tumor cells rely on extracellular amino acids to survive upon glutamine deprivation |
| Authors | Zhang, Nan Yang, Xin Yuan, Fengjie Zhu, Wei-Guo Zhao, Ying |
| Affiliation | Peking Univ, Key Lab Carcinogenesis & Translat Res, Sch Basic Med Sci, Hlth Sci Ctr,Minsit Educ,Dept Biochem & Mol Biol, Beijing, Peoples R China. Shenzhen Univ, Sch Med, Shenzhen, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China. |
| Keywords | Amino acids uptake ATF4 autophagy glutamine NFE2L2 SIRT6 ATF4 Amino acids uptake NFE2L2 SIRT6 autophagy glutamine |
| Issue Date | 2018 |
| Publisher | AUTOPHAGY |
| Citation | AUTOPHAGY. 2018, 14(9), 1652-1653. |
| Abstract | Macroautophagy/autophagy is a unique protein degradation process by which intracellular materials are recycled for energy homeostasis. However, the metabolic status and energy source of autophagy-defective tumor cells is poorly understood. Here in this study, we found ATF4-dependent amino acid transporter (AAT) gene expression and amino acid uptake were increased in autophagy-deficient cells under conditions of Gln deprivation. Notably, inhibition of amino acid uptake reduced the viability of Gln-deprived autophagy-deficient cells, but not significantly in wild-type cells, suggesting the reliance of autophagy-deficient tumor cells on extracellular amino acid uptake. |
| URI | http://hdl.handle.net/20.500.11897/517439 |
| ISSN | 1554-8627 |
| DOI | 10.1080/15548627.2018.1493314 |
| Indexed | SCI(E) PubMed Medline |
| Appears in Collections: | 基础医学院 |
