| Title | BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification |
| Authors | Liu, Xiaoxiao Cao, Fangying Liu, Shuang Mi, Yuhong Liu, Jinghua |
| Affiliation | Capital Med Univ, Beijing Anzhen Hosp, Emergency & Crit Care Ctr, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China. Nanchang Univ, Affiliated Hosp 2, Dept Cardiol, Nanchang, Jiangxi, Peoples R China. Peking Univ, Int Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China. Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China. |
| Keywords | Fibroblast growth factor21 Vascular calcification BMP2/Smad signaling pathway Osteoblast differentiation Noggin SMOOTH-MUSCLE-CELLS OSTEOBLAST DIFFERENTIATION IN-VITRO RECEPTOR COMPLEX PROTEIN TRANSCRIPTION MECHANISMS MUTATION THERAPY FGF-21 |
| Issue Date | 2018 |
| Publisher | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| Citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018, 503(2), 930-937. |
| Abstract | Vascular calcification is extremely common and associated with major adverse cardiovascular events. Fibroblast growth factor (FGF) 21 has been identified as a potent metabolic regulator and a protector of the cardiovascular system. In this study, we aimed to investigate the effect of FGF21 on calcification of vascular smooth muscle cell (VSMC) and its mechanism. FGF21 inhibited beta-glycerophosphate (BGP) induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. FGF21 suppressed BGP-induced BMP2/Smad signaling pathway components as well as osteoblast differentiation markers. FGF21 and Noggin could synergistically inhibit BGP-induced BMP2/Smad pathway expressions and calcification. Taken together, FGF21 inhibits vascular calcification in vitro by modulating BMP2/Smad signaling pathway. (C) 2018 Published by Elsevier Inc. |
| URI | http://hdl.handle.net/20.500.11897/517415 |
| ISSN | 0006-291X |
| DOI | 10.1016/j.bbrc.2018.06.098 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 国际医院 |
