| Title | Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications |
| Authors | Wu, Rui Ding, Xiaokang Qi, Yu Zeng, Qiang Wu, Yu-Wei Yu, Bingran Xu, Fu-Jian |
| Affiliation | Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Key Lab Carbon Fiber & Funct Polymers, Minist Educ,Beijing Lab Biomed Mat,Beijing Adv In, Beijing 100029, Peoples R China. Peking Univ, Sch & Hosp Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 10010, Peoples R China. Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Key Lab Carbon Fiber & Funct Polymers, Minist Educ,Beijing Lab Biomed Mat,Beijing Adv In, Beijing 100029, Peoples R China. Wu, YW (reprint author), Peking Univ, Sch & Hosp Stomatol, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 10010, Peoples R China. |
| Keywords | cationic nanoparticles dopamine gene therapy imaging photodynamic therapy FUNCTIONALIZED POLY(GLYCIDYL METHACRYLATE) EFFICIENT GENE DELIVERY PHOTODYNAMIC THERAPY NONVIRAL DELIVERY CANCER-CELLS ROSE-BENGAL CARRIERS DNA COMBINATION CHALLENGES |
| Issue Date | 2018 |
| Publisher | SMALL |
| Citation | SMALL. 2018, 14(22). |
| Abstract | One challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene transfection performances. Herein, a series of multifunctional cationic nanoparticles (PRP) consisting of photosensitizer cores and PGED shells are readily developed through simple dopamine-involving processes for versatile bioapplications. A series of experiments demonstrates that PRP nanoparticles are able to effectively mediate gene delivery in different cell lines. PRP nanoparticles are further validated to possess remarkable capability of combined PDT and gene therapy for complementary tumor treatment. In addition, because of their high dispersities in biological matrix, the PRP nanoparticles can also be used for in vitro and in vivo imaging with minimal aggregation-caused quenching. Therefore, such flexible nanoplatforms with photosensitizer cores and polycationic shells are very promising for multimodal tumor therapy with high efficacy. |
| URI | http://hdl.handle.net/20.500.11897/513231 |
| ISSN | 1613-6810 |
| DOI | 10.1002/smll.201800201 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 口腔医院 |
