| Title | Suicide Attempt, Clinical Correlates, and BDNF Val66Met Polymorphism in Chronic Patients With Schizophrenia |
| Authors | Xia, Haisen Zhang, Guangya Du, Xiangdong Zhang, Yingyang Yin, Guangzhong Dai, Jing He, Man-Xi Soares, Jair C. Li, Xiaosi Zhang, Xiang Yang |
| Affiliation | Hefei Fourth Peoples Hosp, Anhui Mental Hlth Ctr, 316 Huangshan Rd, Hefei 230071, Anhui, Peoples R China. Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China. Fourth Peoples Hosp Chengdu, Chengdu Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China. Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA. Peking Univ, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China. Hefei Fourth Peoples Hosp, Anhui Mental Hlth Ctr, 316 Huangshan Rd, Hefei 230071, Anhui, Peoples R China. Zhang, XY (reprint author), Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China. Zhang, XY (reprint author), Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China. |
| Keywords | schizophrenia suicide attempt BDNF polymorphism association NEUROTROPHIC FACTOR GENE QUALITY-OF-LIFE RISK-FACTORS VA166MET POLYMORPHISM 1ST-EPISODE PSYCHOSIS BEHAVIOR METAANALYSIS ASSOCIATION SERUM DISORDER |
| Issue Date | 2018 |
| Publisher | NEUROPSYCHOLOGY |
| Citation | NEUROPSYCHOLOGY. 2018, 32(2), 199-205. |
| Abstract | Objective: Recent evidence suggests the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior. Because schizophrenia patients usually have high suicide rates and numerous studies have suggested that BDNF may contribute to the psychopathology of schizophrenia, we hypothesized that the functional polymorphism of BDNF (Val66Met) was associated with suicide attempts in patients with schizophrenia in a Chinese Han population. Method: This polymorphism was genotyped in 825 chronic schizophrenia patients with (n = 123) and without (n = 702) suicide attempts and 445 healthy controls without a history of suicide attempts using a case-control design. The schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale. Results: There were no significant differences in BDNF Val66Met genotype and allele distributions between the patients and healthy controls. However, we found the Val allele (p = .023) and the Val/Val genotypes (p = .058) to be associated with a history of suicide attempts. Moreover, some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophrenia patients. Conclusions: The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients. |
| URI | http://hdl.handle.net/20.500.11897/510991 |
| ISSN | 0894-4105 |
| DOI | 10.1037/neu0000383 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 北京回龙观医院 |
