| Title | A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant |
| Authors | Zhan, Wei Ji, Ling Ge, Ze-mei Wang, Xin Li, Run-tao |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China. |
| Keywords | Hydrolysis of nitriles Continuous flow chemistry Green chemistry Hydrogen peroxide CATALYZED ONE-POT MICROWAVE IRRADIATION DIRECT CONVERSION CARBOXYLIC-ACIDS EFFICIENT HYDRATION ALDEHYDES MILD ORGANONITRILES OXIDATION |
| Issue Date | 2018 |
| Publisher | TETRAHEDRON |
| Citation | TETRAHEDRON. 2018, 74(13), 1527-1532. |
| Abstract | A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant has been developed. Using this procedure, a variety of nitrites could be smoothly transformed into the desired primary amides in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up. (C) 2018 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/507110 |
| ISSN | 0040-4020 |
| DOI | 10.1016/j.tet.2018.02.017 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
