| Title | Long non-coding RNAs in rheumatoid arthritis |
| Authors | Li, Zheng Li, Xingye Jiang, Chao Qian, Wenwei Tse, Gary Chan, Matthew T. V. Wu, William K. K. |
| Affiliation | Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China. Peking Union Med Coll, Beijing, Peoples R China. Tsinghua Univ, Jishuitan Orthopaed Coll, Beijing Jishuitan Hosp, Dept Orthoped Surg,Clin Coll 4,Peking Univ, Beijing, Peoples R China. Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Orthopaed, Shaoxing, Zhejiang, Peoples R China. Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China. Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Hong Kong, Peoples R China. Chinese Univ Hong Kong, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China. Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China. Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China. Qian, WW (reprint author), Peking Union Med Coll, Beijing, Peoples R China. |
| Keywords | AUTOIMMUNE-DISEASES SIGNALING PATHWAY EXPRESSION PROFILE EMERGING ROLE P53 ACTIVITY T-CELL PATHOGENESIS CANCER ATHEROSCLEROSIS THERAPY |
| Issue Date | 2018 |
| Publisher | CELL PROLIFERATION |
| Citation | CELL PROLIFERATION. 2018, 51(1). |
| Abstract | Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that longnon-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-B signalling and T-cell response pertinent to autoimmunity and inflammation.Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful. |
| URI | http://hdl.handle.net/20.500.11897/506974 |
| ISSN | 0960-7722 |
| DOI | 10.1111/cpr.12404 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京积水潭医院 |
