| Title | Rest but busy: Aberrant resting-state functional connectivity of triple network model in insomnia |
| Authors | Dong, Xiaojuan Qin, Haixia Wu, Taoyu Hu, Hua Liao, Keren Cheng, Fei Gao, Dong Lei, Xu |
| Affiliation | Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China. Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China. Peking Univ, Beijing Key Lab Behav & Mental Hlth, PKU IDG McGovern Inst Brain Res, Sch Psychol & Cognit Sci, Beijing, Peoples R China. Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China. Third Mil Med Univ, Daping Hosp, Sleep Psychol Ctr, Chongqing, Peoples R China. Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China. Gao, D (reprint author), Third Mil Med Univ, Daping Hosp, Sleep Psychol Ctr, Chongqing, Peoples R China. |
| Keywords | hyperarousal insomnia disorder large-scale brain networks resting-state fMRI PSYCHOMOTOR VIGILANCE TASK COGNITIVE-BEHAVIORAL THERAPY OBSTRUCTIVE SLEEP-APNEA DEFAULT-MODE FRONTOPARIETAL CONTROL WORKING-MEMORY PERFORMANCE BRAIN FMRI NEUROFEEDBACK |
| Issue Date | 2018 |
| Publisher | BRAIN AND BEHAVIOR |
| Citation | BRAIN AND BEHAVIOR. 2018, 8(2). |
| Abstract | Introduction: One classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting-state large-scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large-scale brain networks in patients with insomnia disorder (ID) during resting state. Methods: In the present study, the resting-state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs). The Pearson's correlation analysis was employed to explore whether the abnormal FNC observed in patients with ID was associated with sleep parameters, cognitive and emotional scores, and behavioral performance assessed by questionnaires and tasks. Results: Patients with ID had worse subjective thought control ability measured by Thought Control Ability Questionnaire (TCAQ) and more negative affect than HGSs. Intriguingly, relative to HGSs, patients with ID showed a significant increase in FNC between DAN and FPC, but a significant decrease in FNC between aDMN and pDMN. Exploratory analysis in patients with ID revealed a significantly positive correlation between the DAN-FPC FNC and reaction time (RT) of psychomotor vigilance task (PVT). Conclusion: The current study demonstrated that even during the resting state, the task-activated and task-deactivated large-scale brain networks in insomniacs may still maintain a hyperarousal state, looking quite similar to the pattern in a task condition with external stimuli. Those results support the hyperarousal model of insomnia. |
| URI | http://hdl.handle.net/20.500.11897/506968 |
| ISSN | 2162-3279 |
| DOI | 10.1002/brb3.876 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 心理与认知科学学院 行为与心理健康北京市重点实验室 |
