| Title | A novel scoring system to predict ascites development post hepatectomy for BCLC stage B hepatocellular carcinoma |
| Authors | Qian, Hong-Gang Wu, Li-Ying Li, Cheng-Peng Lv, Ang Wu, Jian-Hui Liu, Bo-Nan Tian, Xiu-Yun Xu, Wei Hao, Chun-Yi |
| Affiliation | Peking Univ, Canc Hosp & Inst, Dept Hepatopancreatobiliary Surg, Key Lab Carcinogenesis & Translat Res Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China. Saskatchewan Hlth Qual Council, Saskatoon, SK, Canada. |
| Keywords | Hepatocellular carcinoma (HCC) ascites prediction scoring system hepatectomy CLINICAL-PRACTICE GUIDELINES HEPATITIS-C PATIENTS LIVER RESECTION RISK-FACTORS CIRRHOSIS MANAGEMENT VIRUS ASSOCIATION FIBROSIS MORTALITY |
| Issue Date | 2018 |
| Publisher | TRANSLATIONAL CANCER RESEARCH |
| Citation | TRANSLATIONAL CANCER RESEARCH. 2018, 7(1), 180-188. |
| Abstract | Background: To develop a novel scoring system to predict the development of post-operative ascites by analyzing clinicopathological characteristics and risk factors of BCLC stage B hepatocellular carcinoma. Methods: Prospective analysis was performed on consecutive patients with BCLC stage B hepatocellular carcinoma, who underwent hepatectomy from January 2005 to December 2014. Results: A total of 181 patients were enrolled, of whom 34.3% (62/181) developed post-operative ascites. Comparing with patients without ascites, patients who developed ascites had longer drain placement, more incidence of pleural effusion, more incidence of intra-abdominal infection and longer inpatient stay. All differences were statistically significant (P<0.01). A univariate analysis showed that the following factors were associated with the development of ascites: gender, prothrombin time (PT), prothrombin activity (PTA), platelet count (PLT), aspartate transaminase (AST), duration of operation, future liver remnant (FLR) <50%, blood loss, and transfusion of plasma or red blood cells during operation. On multivariate analysis, PLT, FLR <50%, transfusion of plasma or red blood cell during operation were independently associated with post-operative ascites accumulation. A predictive scoring system was established using the factors above and the patients with scores >= 5 had high risk of developing post-operative ascites [sensitivity =96.8%, specificity =90.8%, and area under the curve (AUC) =0.972]. Conclusions: The development of post-operative ascites was associated with various clinicopathological factors. The scoring system, which incorporates these factors, provided a valuable means for predicting the development of post-operative ascites. Early identification of these at-risk patients might help to improve their perioperative outcome. |
| URI | http://hdl.handle.net/20.500.11897/506941 |
| ISSN | 2218-676X |
| DOI | 10.21037/tcr.2018.01.35 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
