| Title | Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease |
| Authors | An, Chunna Pu, Xiaoping Xiao, Weizhong Zhang, Hongning |
| Affiliation | North China Univ Sci & Technol, Sch Basic Med Sci, Dept Pharmacol, Tangshan, Peoples R China. Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing, Peoples R China. Peking Univ, Hosp 3, Dept Neurol, Beijing, Peoples R China. Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, 10 West 1st Rd, Beijing 100069, Peoples R China. |
| Keywords | Parkinson's disease Chinese Serum DJ-1 ALPHA-SYNUCLEIN MUTATIONS PROGRESSION CHAPERONE STRESS |
| Issue Date | 2018 |
| Publisher | NEUROSCIENCE LETTERS |
| Citation | NEUROSCIENCE LETTERS. 2018, 665, 236-239. |
| Abstract | DJ-1 is one of the important genes found in Parkinson's disease (PD). Studies have shown that the DJ-1 protein levels are elevated in the cerebrospinal fluid (CSF) and plasma of sporadic PD patients, and the DJ-1 protein levels in the CSF and plasma may serve as biomarkers of PD. However, Japanese scholars previously reported that there was no difference in the levels of the DJ-1 protein in serum between sporadic PD patients and controls. Therefore, whether the serum DJ-1 protein levels are different between PD patients and controls in Chinese patients as well as whether serum DJ-1 protein can serve as a biomarker of PD are unknown. The present study aimed to determine whether there was a difference in serum DJ-1 protein levels between Chinese PD patients and controls. The subjects included 18 primary PD patients and 7 controls. Blood was collected by venipuncture, and serum was collected by centrifugation after the blood was coagulated. The serum DJ-1 protein levels were detected by both Western blot and ELISA. There were differences in the serum DJ-1 protein levels among. different individuals. The serum DJ-1 concentration in PD patients was 11.3 +/- 10.1 ng/ml, and that in controls was 18.1 +/- 12.8 ng/ml (P > 0.05). In conclusion, similar to the study conducted by Japanese scholars, we found no significant difference in the serum DJ-1 protein levels between PD patients and controls in Chinese subjects. The levels of the DJ-1 protein in serum may not be a biomarker of PD. In addition, there may be differences in the serum DJ-1 protein levels between Chinese and Japanese patients. |
| URI | http://hdl.handle.net/20.500.11897/502732 |
| ISSN | 0304-3940 |
| DOI | 10.1016/j.neulet.2017.12.023 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 第三医院 |
