| Title | Cortical frequency-specific plasticity is independently induced by intracortical circuitry |
| Authors | Kong, Lingzhi Wang, Shaohui Liu, Xiuping Li, Liang Zeeman, Michael Yan, Jun |
| Affiliation | Univ Calgary, Cumming Sch Med, Hotchkiss Brain Inst, Dept Physiol & Pharmacol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada. Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China. Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China. Beijing Language & Culture Univ, Allied Hlth Sch, Beijing 100871, Peoples R China. |
| Keywords | Auditory Cortex Thalamus Mouse Plasticity PRIMARY AUDITORY-CORTEX RECEPTIVE-FIELD PLASTICITY ELECTRICAL-STIMULATION CORTICOFUGAL FEEDBACK PHYSIOLOGICAL MEMORY INFERIOR COLLICULUS NEURONS REORGANIZATION MICROSTIMULATION MODULATION |
| Issue Date | 2018 |
| Publisher | NEUROSCIENCE LETTERS |
| Citation | NEUROSCIENCE LETTERS. 2018, 668, 13-18. |
| Abstract | Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contributions of the thalamocortical inputs are controlled. Here, we induced cortical plasticity by local activation of the primary auditory cortex (AI) via intracortical electrical stimulation (ES) in C57 mice and found a similar pattern of cortical plasticity was induced by ESA/when the auditory thalamus was inactivated or remained active during the ESAI. The best frequencies (BFs) of the recorded cortical neurons shifted towards the BFs of the electrically stimulated ones. In addition, the BF shifts were linearly correlated to the BF differences between the recorded and stimulated cortical neurons. More importantly, the ratio of the linear function with thalamic inactivation was nearly the same as the ratio of the linear function in the control condition. Our data show that cortical frequency-specific plasticity was induced by ESA/with or without the thalamic inactivation; thus intracortical circuitry can be independently responsible for cortical frequency-specific plasticity. |
| URI | http://hdl.handle.net/20.500.11897/502633 |
| ISSN | 0304-3940 |
| DOI | 10.1016/j.neulet.2017.12.044 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 心理与认知科学学院 |
