Title | Antimicrobial blue light inactivation of pathogenic microbes: State of the art |
Authors | Wang, Yucheng Wang, Ying Wang, Yuguang Murray, Clinton K. Hamblin, Michael R. Hooper, David C. Dai, Tianhong |
Affiliation | Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA. Aviat Gen Hosp, Canc Ctr, Beijing, Peoples R China. Chinese Acad Sci, Beijing Inst Translat Med, Dept Med Oncol, Beijing, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing, Peoples R China. Peking Univ, Sch & Hosp Stomatol, Ctr Digital Dent, Beijing, Peoples R China. San Antonio Mil Med Ctr, Infect Dis Serv, JBSA Ft Sam Houston, TX USA. Harvard Med Sch, Massachusetts Gen Hosp, Div Infect Dis, Boston, MA USA. Massachusetts Gen Hosp, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA. |
Keywords | Antimicrobial blue light Non-antibiotic approach Endogenous photosensitizer Antibiotic resistance Microbe Bacterium Fungus Infection RESISTANT STAPHYLOCOCCUS-AUREUS 405 NM LIGHT CARE-ASSOCIATED INFECTIONS EMITTING DIODE ILLUMINATION INDUCED OXIDATIVE STRESS MRSA IN-VITRO ESCHERICHIA-COLI VISIBLE-LIGHT LISTERIA-MONOCYTOGENES ENDOGENOUS PORPHYRINS |
Issue Date | 2017 |
Publisher | DRUG RESISTANCE UPDATES |
Citation | DRUG RESISTANCE UPDATES. 2017, 33-35, 1-22. |
Abstract | As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400-470 run has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed. |
URI | http://hdl.handle.net/20.500.11897/500987 |
ISSN | 1368-7646 |
DOI | 10.1016/j.drup.2017.10.002 |
Indexed | SCI(E) PubMed |
Appears in Collections: | 口腔医院 |