| Title | Inverse correlation of V2(+) T-cell recovery with EBV reactivation after haematopoietic stem cell transplantation |
| Authors | Liu, Jiangying Bian, Zhilei Wang, Xiaoyu Xu, Lan-Ping Fu, Qiang Wang, Chenguang Chang, Ying-Jun Wang, Yu Zhang, Xiao-Hui Jiang, Zhengfan Huang, Xiao-Jun |
| Affiliation | Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplant, Beijing, Peoples R China. Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing, Peoples R China. Peking Univ, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China. |
| Keywords | haematopoietic stem cell transplantation immune reconstitution Epstein-Barr virus (EBV) gamma delta T V delta 2 cells LYMPHOPROLIFERATIVE DISEASE IMMUNE RECONSTITUTION LYMPHOCYTES RISK PREVENTION RECIPIENTS LEUKEMIA OUTCOMES ADULTS BLOOD |
| Issue Date | 2018 |
| Publisher | BRITISH JOURNAL OF HAEMATOLOGY |
| Citation | BRITISH JOURNAL OF HAEMATOLOGY. 2018, 180(2), 276-285. |
| Abstract | Epstein-Barr virus (EBV) reactivation remains a life-threatening complication in recipients of a haploidentical haematopoietic stem cell transplantation (haploHSCT). Reconstitution of adaptive T lymphocytes is generally compromised at the early stages following transplant, suggesting an important role of other effector cells in preventing EBV infection. Our previous studies demonstrated that recovery of CD4(-)CD8(-) T cells negatively correlated with EBV reactivation after haploHSCT. In this prospective study on 132 adult patients with haematopoietic malignancy, recovery of T-cell subpopulations was characterized post-haploHSCT. We showed that the median counts of peripheral V delta 2 cells were continuously lower in recipients with EBV reactivation compared with controls at 30, 60 and 90days after haploHSCT (P values: 0.006, <0.001 and 0.019, respectively). Landmark study further indicated that the cumulative incidence of EBV reactivation was significantly decreased in recipients with higher day-30 V delta 2 counts. Activation of V delta 2 cells upon EBV reactivation was accompanied by an induction of cell apoptosis. Cytotoxic effect of V delta 2 cells on EBV-infected cells was confirmed by invitro experiments. Together, our findings uncovered a significant correlation of recovered V delta 2 with EBV reactivation following haploHSCT. These results will help to better understand the intrinsic anti-virus immunity and develop gamma delta T-based therapy strategies after haematopoietic transplantation. |
| URI | http://hdl.handle.net/20.500.11897/500096 |
| ISSN | 0007-1048 |
| DOI | 10.1111/bjh.15037 |
| Indexed | SCI(E) PubMed Medline |
| Appears in Collections: | 人民医院 生命科学学院 |
