| Title | Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes |
| Authors | Yu, Xinhe Gao, Duo Gao, Liquan Lai, Jianhao Zhang, Chenran Zhao, Yang Zhong, Lijun Jia, Bing Wang, Fan Chen, Xiaoyuan Liu, Zhaofei |
| Affiliation | Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Med Isotopes Res Ctr, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China. Peking Univ, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China. Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China. Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Med Isotopes Res Ctr, Beijing 100191, Peoples R China. Liu, ZF (reprint author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China. |
| Keywords | graphene oxide photodynamic therapy immunotherapy immunological memory tumor vaccine ANTITUMOR IMMUNITY TGF-BETA IN-VIVO CANCER-IMMUNOTHERAPY GRAPHENE OXIDE BREAST-CANCER NANO-GRAPHENE CELL-DEATH BIOMEDICAL APPLICATIONS CHECKPOINT BLOCKADE |
| Issue Date | 2017 |
| Publisher | ACS NANO |
| Citation | ACS NANO. 2017, 11(10), 10147-10158. |
| Abstract | Effective cancer therapy depends not only on destroying the primary tumor but also on conditioning the host immune system to recognize and eliminate residual tumor cells and prevent metastasis. In this study, a tumor integrin av beta 6-targeting peptide (the HK peptide)-functionalized graphene oxide (GO) was coated with a photo sensitizer (HPPH). The resulting GO conjugate, GO(HPPH)-PEG-HK, was investigated whether it could destroy primary tumors and boost host antitumor immunity. We found that GO (HPPH)-PEG-HK exhibited significantly higher tumor uptake than GO(HPPH)-PEG and HPPH. Photodynamic therapy (PDT) using GO(HPPH)-PEG suppressed tumor growth in both subcutaneous and lung metastatic mouse models. Necrotic tumor cells caused by GO(HPPH)-PEG-HK PDT activated dendritic cells and significantly prevented tumor growth and lung metastasis by increasing the infiltration of cytotoxic CD8+ T lymphocytes within tumors as evidenced by in vivo optical and single-photon emission computed tomography (SPECT)/CT imaging. These results demonstrate that tumor-targeted PDT using GO(HPPH)-PEG-HK could effectively ablate primary tumors and destroy residual tumor cells, thereby preventing distant metastasis by activating host antitumor immunity and suppressing tumor relapse by stimulation of immunological memory. |
| URI | http://hdl.handle.net/20.500.11897/497874 |
| ISSN | 1936-0851 |
| DOI | 10.1021/acsnano.7b04736 |
| Indexed | SCI(E) EI PubMed Medline |
| Appears in Collections: | 基础医学院 |
