| Title | Association between peripheral gamma delta T cell subsets and disease progression of severe fever with thrombocytopenia syndrome virus infection |
| Authors | Xu, Wen Li, Xiao-Kun Lu, Qing-Bin Yang, Zhen-Dong Du, Juan Xing, Bo Cui, Ning Zhang, Xiao-Ai Zhang, Shao-Fei Yang, Xin-Xin Liu, Wei Chen, Wei-Wei |
| Affiliation | 302 Hosp, Peoples Liberat Army, Treatment & Res Ctr Infect Dis, 100,West 4th Ring Rd, Beijing 100039, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, 20 Dong Da St, Beijing 100071, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Peking Univ, Sch Publ Hlth, Beijing Key Lab Toxicol Res & Risk Assessment Foo, 38 Xueyuan Rd, Beijing 100191, Peoples R China. 154 Hosp, Peoples Liberat Army, Dept Infect Dis, 104 Nan Hu Rd, Xinyang 464000, Peoples R China. |
| Keywords | gamma delta T cells SFTSV disease progression prospective study LYMPHOCYTES CHINA HIV REPLICATION STIMULATION RECEPTORS EXPANSION RESPONSES AIDS |
| Issue Date | 2017 |
| Publisher | PATHOGENS AND DISEASE |
| Citation | PATHOGENS AND DISEASE. 2017, 75(7). |
| Abstract | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus. The cellular immune responses during SFTS virus infection have not been fully understood. This study examined the association between circulating gamma delta T cell subsets and clinical outcome of SFTS patients from China. A total of 101 hospitalized SFTS patients and 28 healthy controls were enrolled. Peripheral blood was collected, and lymphocyte subgroups and gamma delta T cell frequencies were evaluated by flow cytometry analysis. Their association with patients' outcome was also investigated. Starting from Week 1, the V delta 1 cells of patients were increased to significantly higher level at Month 3 after disease onset than the controls (P < 0.05), followed by a decrease to the normal level in Year 1. In contrast, the V delta 2 cells displayed significant lower level than the controls from Week 2 to Year 1. On Week 2, the V delta 2 cells demonstrated a significant decrease in the severe patients than both the mild and controls (P < 0.05). The adverse disease progression is accompanied by the reduction of V delta 2 cells, suggesting the key role of V delta 2 cells in the disease progression. |
| URI | http://hdl.handle.net/20.500.11897/497858 |
| ISSN | 2049-632X |
| DOI | 10.1093/femspd/ftx086 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
