| Title | Aggregation Induced Emission Fluorogens Based Nanotheranostics for Targeted and Imaging-Guided Chemo-Photothermal Combination Therapy |
| Authors | Wang, Ke Fan, Xingliang Zhao, Lingyun Zhang, Xiaoyong Zhang, Xiqi Li, Zhen Yuan, Qian Zhang, Qingsong Huang, Zengfang Xie, Wensheng Zhang, Yuanyuan Wei, Yen |
| Affiliation | Tsinghua Univ, Dept Chem, Minist Educ, Beijing 100084, Peoples R China. Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China. Tsinghua Univ Peking Univ, Joint Ctr Life Sci, Beijing 100084, Peoples R China. Tsinghua Univ, Dept Biomed Engn, Sch Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing 100084, Peoples R China. Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing 100084, Peoples R China. Tsinghua Univ, Dept Chem, Minist Educ, Beijing 100084, Peoples R China. Wei, Y (reprint author), Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China. |
| Keywords | aggregation induced emission,combination therapy,fluorescence imaging,nanotheranostics,targets THERANOSTIC APPLICATIONS POLYMER NANOPARTICLES GRAPHENE OXIDE CANCER-THERAPY FE5C2 NANOPARTICLES DRUG-DELIVERY TUMOR-THERAPY QUANTUM DOTS FLUORESCENT ALBUMIN |
| Issue Date | 2016 |
| Publisher | SMALL |
| Citation | SMALL.2016,12(47),6568-6575. |
| Abstract | Nanotheranostics for biomedical imaging-guided cancer therapy have attracted increasing interest due to their capabilities of both precise tumor diagnosis and high therapeutic efficacy. Among the diverse imaging models, fluorescence imaging have been extensively researched for their high sensitivity, simple operation, and low cost. In this work, aggregation induced emission (AIE) fluorogens based targeted nanotheranostics are facilely fabricated via paclitaxel (PTX) induced assembly of proteins for the first time. Thanks to the unique fluorescence property of AIE fluorogens PhENH2, the prepared theranostic nanoplatforms can emit bright fluorescence even after being incorporated with the photothermal therapy agent polypyrrole (PPy), which will often decrease or quench the emission of common fluorescence dyes. The target moiety of cyclic arginine-glycine-aspartic acid (cRGD) endows the nanotheranostics with outstanding targeting ability, which can further facilitate the targeted imaging and cancer treatment. As revealed by the in vitro and in vivo experiments, the prepared nanotheranostics human serum albumin-PhENH2-PPy- PTX-cRGD shows impressive performance in the targeted fluorescence imaging even after intravenous injection for 48 h, and their combined chemo-photothermal therapy is also very effective. These results indicate that AIE fluorogens based nanotheranostics would find a promising prospect in further improved multimodal imaging and imaging guided cancer treatment. |
| URI | http://hdl.handle.net/20.500.11897/493130 |
| ISSN | 1613-6810 |
| DOI | 10.1002/smll.201601473 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 生命科学学院 |
