| Title | Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase |
| Authors | Song, Xinhua Yin, Shutao Zhang, Enxiang Fan, Lihong Ye, Min Zhang, Yong Hu, Hongbo |
| Affiliation | China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China. China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China. Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China. China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China. Ye, M (reprint author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. |
| Keywords | licorice glycycoumarin anti-liver cancer T-LAK cell-originated protein kinase p53 HEPATOCELLULAR-CARCINOMA GLYCYRRHIZA-URALENSIS LICORICE ISOANGUSTONE FLAVONOIDS PROLIFERATION EXPRESSION GROWTH RADIX P53 |
| Issue Date | 2016 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2016,7(40),65732-65743. |
| Abstract | Glycycoumarin (GCM) is a major bioactive coumarin compound isolated from licorice and the anti-cancer activity of GCM has not been scientifically addressed. In the present study, we have tested the anti-liver cancer activity of GCM using both in vitro and in vivo models and found for the first time that GCM possesses a potent activity against liver cancer evidenced by cell growth inhibition and apoptosis induction in vitro and tumor reduction in vivo. Mechanistically, GCM was able to bind to and inactivate oncogenic kinase T-LAK cell-originated protein kinase (TOPK), which in turn led to activation of p53 pathway. Our findings supported GCM as a novel active compound that contributed to the anti-cancer activity of licorice and TOPK could be an effective target for hepatocellular carcinoma (HCC) treatment. |
| URI | http://hdl.handle.net/20.500.11897/493048 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.11610 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
