| Title | Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population |
| Authors | Yang, Tian Zeng, Hongmei Chen, Wanqing Zheng, Rongshou Zhang, Yang Li, Zhexuan Qi, Jun Wang, Minjie Chen, Tianhui Lou, Jianlin Lu, Lingeng Zhou, Tong Dai, Shuyang Cai, Meng You, Weicheng Pan, Kaifeng |
| Affiliation | Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Dept Canc Epidemiol,Sch Oncol,Canc Hosp & Inst, Beijing, Peoples R China. Chinese Acad Med Sci, Natl Off Canc Prevent & Control, Natl Canc Ctr Canc Hosp, Beijing, Peoples R China. Peking Union Med Coll, Beijing, Peoples R China. Chinese Acad Med Sci, Natl Canc Ctr Canc Hosp, Dept Clin Lab, Beijing, Peoples R China. Zhejiang Acad Med Sci ZJAMS, Inst Occupat Dis, Grp Mol Epidemiol & Canc Precis Prevent GMECPP, Hangzhou, Zhejiang, Peoples R China. Zhejiang Acad Med Sci ZJAMS, Inst Occupat Dis, Hangzhou, Zhejiang, Peoples R China. Yale Univ, Yale Canc Ctr, Sch Med, Dept Chron Dis Epidemiol,Yale Sch Publ Hlth, New Haven, CT USA. Chinese Acad Med Sci, Natl Canc Ctr Canc Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China. Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Dept Canc Epidemiol,Sch Oncol,Canc Hosp & Inst, Beijing, Peoples R China. Zeng, HM (reprint author), Chinese Acad Med Sci, Natl Off Canc Prevent & Control, Natl Canc Ctr Canc Hosp, Beijing, Peoples R China. |
| Keywords | Gastric cancer Long non-coding RNA Serum Helicobacter pylori Biomarkers NONCODING RNA LINC00152 PROMOTES PROLIFERATION POOR-PROGNOSIS LONG BIOMARKER PLASMA IDENTIFICATION CONTRIBUTES CARCINOMA DIAGNOSIS |
| Issue Date | 2016 |
| Publisher | CANCER EPIDEMIOLOGY |
| Citation | CANCER EPIDEMIOLOGY.2016,44,147-153. |
| Abstract | Gastric cancer (GC) is a consequence of multifactorial and multistep processes. Helicobacter pylori (H. pylori) infection plays a crucial role in gastric carcinogenesis. Long non-coding RNAs (lncRNAs) have shown great potential as powerful cancer biomarkers. To investigate the possible roles of lncRNAs and H. pylori infection in GC development, we measured expression levels of three lncRNAs (H19, LINC00152, uc001lsz) in serum from a total of 285 Chinese participants using reverse transcription-quantitative polymerase chain reaction. We found significant associations between high expression of both H19 and LINC00152 in serum and increased risk of GC; the adjusted OR for H19 was 2.17 (95% CI: 1.21-3.88), and for LINC00152 was 2.09 (95% CI: 1.18-3.70). Further analyses indicated an elevated risk of GC in subjects with both high H19 expression and H. pylori infection (OR: 13.75, 95% CI: 4.75-39.84). Significant joint effect between LINC00152 and H. pylori infection on risk of GC was also found (OR: 17.49, 95% CI: 4.78-63.92). Serum H19 and LINC00152 may serve as potential biomarkers for diagnosis of GC, particularly for those with H. pylori infection. (C) 2016 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/493015 |
| ISSN | 1877-7821 |
| DOI | 10.1016/j.canep.2016.08.015 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
