| Title | Molecular characteristics and antimicrobial resistance in invasive and noninvasive Group B Streptococcus between 2008 and 2015 in China |
| Authors | Lu, Binghuai Chen, Xingchun Wang, Junrui Wang, Duochun Zeng, Ji Li, Yi Li, Dong Zhu, Fengxia Cui, Yanchao Huang, Lei |
| Affiliation | Civil Aviat Gen Hosp, Dept Lab Med, Beijing 100123, Peoples R China. Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Lab Med, Nanning 530021, Peoples R China. Inner Mongolia Med Univ, Affiliated Hosp, Dept Clin Lab, Hohhot 010050, Peoples R China. Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China. Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China. Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China. Huazhong Univ Sci & Technol, Wuhan Pu Ai Hosp, Dept Lab Med, Wuhan 430034, Peoples R China. Henan Prov Peoples Hosp, Dept Lab Med, Zhengzhou 450003, Peoples R China. Peking Univ, Hosp 1, Dept Lab Med, Beijing 100034, Peoples R China. |
| Keywords | Group B Streptococcus Serotyping Pilus islands alpha-Like protein genes Multilocus sequence typing Antimicrobial resistance profile NONPREGNANT ADULTS PILUS ISLANDS SURFACE-PROTEINS MULTIPLEX PCR AGALACTIAE EPIDEMIOLOGY INFECTIONS SEROTYPE DISEASE GENES |
| Issue Date | 2016 |
| Publisher | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE |
| Citation | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE.2016,86(4),351-357. |
| Abstract | Group B streptococcus (GBS) is an increasing pathogen threat to newborns and adults with immunodepressive diseases. Here, a total of 193 GBS, including 51 invasive and 142 noninvasive isolates, were collected from the patients with infections in 7 tertiary hospitals from 5 cities in China during the year 2008 to 2015. The strains of GBS were characterized by classical and molecular techniques for capsular polysaccharide serotyping, genes for pilus island (PI) and et-like protein (alp), and antibiotic resistance profiling. Of 193 isolates, the predominant serotypes were III (45.6%) and Ia (18.7%). All strains carried at least 1 PI gene. The combination of PI-2b and PI-1 was present in 46.1% isolates, followed by PI-2a alone (80, 41.5%) and PI-2b alone (23, 11.9%). The most prevalent alp gene was rib (87, 45.1%), followed by alpha-C (47, 24.4%), epsilon (33, 17.1%), alp2/3 (7, 3.6%) and alp4 (2,1.0%), respectively. The clonal relationships between strains were investigated using multilocus sequence typing. The strains were distinguished into 26 individual sequence typing, and further clustered into 6 clonal complexes. A significant association was noted between the distributions of alp genes, serotyping and PI profiles, such as serotype III-rib-PI + PI-2a, Ib-alpha-C, and Ia-epsilon-PI-2a. No penicillin-resistant strains were detected, and 74.1%, 64.2%, and 68.9% were resistant to erythromycin, clindamycin, and tetracycline, respectively. The infective GBS isolates in China demonstrated epidemical features. (C) 2016 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/492698 |
| ISSN | 0732-8893 |
| DOI | 10.1016/j.diagmicrobio.2016.08.023 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
