| Title | An in-tether sulfilimine chiral center induces beta-turn conformation in short peptides |
| Authors | Lin, Huacan Jiang, Yixiang Hu, Kuan Zhang, Qingzhou He, Chuanxin Wang, Tao Li, Zigang |
| Affiliation | Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China. Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Guangdong, Peoples R China. South Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China. Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China. He, CX (reprint author), Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Guangdong, Peoples R China. Wang, T (reprint author), South Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China. |
| Keywords | RING-CLOSING METATHESIS AMINO-ACIDS CYCLIC PENTAPEPTIDES HELICAL PEPTIDES PROTEINS DESIGN INHIBITORS POTENT SOMATOSTATIN ANTAGONIST |
| Issue Date | 2016 |
| Publisher | ORGANIC & BIOMOLECULAR CHEMISTRY |
| Citation | ORGANIC & BIOMOLECULAR CHEMISTRY.2016,14(42),9993-9999. |
| Abstract | A sulfilimine chiral center in the tether at i, i + 3 positions of short peptides was systematically studied to elucidate the chiralitydriven conformational changes. A rare and unexpected type III beta-turn structure was induced in short peptides by an in-tether chiral center, supported by circular dichroism spectroscopy, NMR and X-ray crystallography. |
| URI | http://hdl.handle.net/20.500.11897/492641 |
| ISSN | 1477-0520 |
| DOI | 10.1039/c6ob01805j |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 化学生物学与生物技术学院 |
