| Title | The relationship of transforming growth factor-beta and lung cancer |
| Authors | Xue, Xinying Zhao, Sheng Zhang, Zhenning Wang, Yamei Chang, Yan Xu, Yali Jiang, Hong Ma, Xiaorong Qian, Jin Guo, Rui Wang, Kaifei Yao, Xiaoyan Gao, Peiliang Deng, Hui Zhang, Mingyue Ao, Ting Lang, Shan Pan, Lei Wang, Jianxin |
| Affiliation | Chinese Peoples Liberat Army Gen Hosp, Dept Resp Dis, Fuxing Rd 28, Beijing, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment Resp Dis, 10 Tieyi Rd, Beijing 100038, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Peking Univ, Sch Clin Med 9, Beijing, Peoples R China. PLA Rocket Force, Gen Hosp, Dept Resp Dis, Beijing, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Resp Dis, Fuxing Rd 28, Beijing, Peoples R China. Pan, L (reprint author), Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment Resp Dis, 10 Tieyi Rd, Beijing 100038, Peoples R China. |
| Keywords | Lung cancer transforming growth factor beta signaling pathway Smad SUPERFAMILY SIGNALING PATHWAYS TUMOR-SUPPRESSOR SMAD4 II RECEPTOR GENE TGF-BETA CELL-LINES MESENCHYMAL TRANSITION TGF-BETA-1 GENE GROWTH-FACTOR-BETA-1 LEVEL PULMONARY ADENOCARCINOMA PROTEOGLYCAN BETAGLYCAN |
| Issue Date | 2016 |
| Publisher | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(6),9766-9780. |
| Abstract | As the No. 1 killing cancer in the world, the incidence of lung cancer is still on the rise across the globe these years, such a trend is particularly apparent in China. To study the molecular mechanism of the occurrence of lung cancer and develop new anti-cancer drugs is an arduous task confronting medical researchers of the whole world. Multiple signaling pathways are involved in the lung carcinogenesis. Transforming Growth Factor-beta family (TGF-beta), known as a multi-functional cytokine superfamily, plays extensively regulatory roles in life activities, including morphogenesis, embryonic development, immunoregulation, healing of wound, as well as inflammation and tumor. Here we review the roles of TGF-beta signal transduction pathway in lung cancer. |
| URI | http://hdl.handle.net/20.500.11897/492514 |
| ISSN | 1940-5901 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京世纪坛医院 |
