| Title | An in-tether sulfilimine chiral center induces helicity in short peptides |
| Authors | Lin, Huacan Jiang, Yixiang Zhang, Qingzhou Hu, Kuan Li, Zigang |
| Affiliation | Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China. |
| Keywords | RING-CLOSING METATHESIS CATALYZED IMINATION STAPLED P53 SIDE-CHAIN SULFIDES SULFOXIDES STABILITY SEQUENCE |
| Issue Date | 2016 |
| Publisher | CHEMICAL COMMUNICATIONS |
| Citation | CHEMICAL COMMUNICATIONS.2016,52(68),10389-10391. |
| Abstract | A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide's secondary structure. Peptide sulfilimines could be prepared by a facile chloramine T oxidation and the two resulting peptide diastereomers showed significant differences in their secondary structures, which were supported by circular dichroism spectroscopy and NMR. |
| URI | http://hdl.handle.net/20.500.11897/492416 |
| ISSN | 1359-7345 |
| DOI | 10.1039/c6cc04508a |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 化学生物学与生物技术学院 |
