| Title | Interplay of Proximal Flow Confluence and Distal Flow Divergence in Patient-Specific Vertebrobasilar System |
| Authors | Yin, Xiaoping Huang, Xu Feng, Yundi Tan, Wenchang Liu, Huaijun Huo, Yunlong |
| Affiliation | Hebei Med Univ, Hosp 2, Dept Med Imaging, Shijiazhuang, Peoples R China. Peking Univ, Dept Mech & Engn Sci, Coll Engn, Beijing, Peoples R China. Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing, Peoples R China. Peking Univ, Shenzhen Grad Sch, Shenzhen, Peoples R China. Hebei Univ, Coll Med, Baoding, Peoples R China. Hebei Med Univ, Hosp 2, Dept Med Imaging, Shijiazhuang, Peoples R China. Huo, YL (reprint author), Peking Univ, Dept Mech & Engn Sci, Coll Engn, Beijing, Peoples R China. Huo, YL (reprint author), Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing, Peoples R China. Huo, YL (reprint author), Hebei Univ, Coll Med, Baoding, Peoples R China. |
| Keywords | HEMODYNAMIC SHEAR-STRESS CORONARY ARTERIAL TREE BLOOD-FLOW JUNCTION MODEL SCALING LAWS ATHEROSCLEROSIS PATTERNS VESSEL ANGLE ENDOTHELIUM |
| Issue Date | 2016 |
| Publisher | PLOS ONE |
| Citation | PLOS ONE.2016,11(7). |
| Abstract | Approximately one-quarter of ischemic strokes involve the vertebrobasilar arterial system that includes the upstream flow confluence and downstream flow divergence. A patient-specific hemodynamic analysis is needed to understand the posterior circulation. The objective of this study is to determine the distribution of hemodynamic parameters in the vertebrobasilar system, based on computer tomography angiography images. Here, the interplay of upstream flow confluence and downstream flow divergence was hypothesized to be a determinant factor for the hemodynamic distribution in the vertebrobasilar system. A computational fluid dynamics model was used to compute the flow fields in patient-specific vertebrobasilar models (n = 6). The inlet and outlet boundary conditions were the aortic pressure waveform and flow resistances, respectively. A 50% reduction of total outlet area was found to induce a ten-fold increase in surface area ratio of low time-averaged wall shear stress (i.e., TAWSS <= 4 dynes/cm(2)). This study enhances our understanding of the posterior circulation associated with the incidence of atherosclerotic plaques. |
| URI | http://hdl.handle.net/20.500.11897/491823 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0159836 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 工学院 深圳研究生院待认领 湍流与复杂系统国家重点实验室 |
