| Title | Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback |
| Authors | Ma, Yina Li, Shiyi Wang, Chenbo Liu, Yi Li, Wenxin Yan, Xinyuan Chen, Qiang Han, Shihui |
| Affiliation | Beijing Normal Univ, McGovern Inst Brain Res, IDG, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China. Peking Univ, Beijing Key Lab Behav & Mental Hlth, McGovern Inst Brain Res, Sch Psychol & Cognit Sci,IDG, Beijing 100080, Peoples R China. Lieber Inst Brain Dev, Baltimore, MD 21205 USA. Beijing Normal Univ, McGovern Inst Brain Res, IDG, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China. Han, SH (reprint author), Peking Univ, Beijing Key Lab Behav & Mental Hlth, McGovern Inst Brain Res, Sch Psychol & Cognit Sci,IDG, Beijing 100080, Peoples R China. |
| Keywords | oxytocin social adaptation confidence belief updating optimism DISPOSITIONAL OPTIMISM PSYCHOLOGICAL RESOURCES HUMANS AVOIDANCE BEHAVIOR ANXIETY HEALTH TRUST UNCERTAINTY ADAPTATION |
| Issue Date | 2016 |
| Publisher | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
| Citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.2016,113(33),9256-9261. |
| Abstract | Humans update their beliefs upon feedback and, accordingly, modify their behaviors to adapt to the complex, changing social environment. However, people tend to incorporate desirable (better than expected) feedback into their beliefs but to discount undesirable (worse than expected) feedback. Such optimistic updating has evolved as an advantageous mechanism for social adaptation. Here, we examine the role of oxytocin (OT). an evolutionary ancient neuropeptide pivotal for social adaptation. in belief updating upon desirable and undesirable feedback in three studies (n = 320). Using a double-blind, placebo-controlled between-subjects design, we show that intranasally administered OT (IN-OT) augments optimistic belief updating by facilitating updates of desirable feedback but impairing updates of undesirable feedback. The IN-OT-induced impairment in belief updating upon undesirable feedback is more salient in individuals with high, rather than with low, depression or anxiety traits. IN-OT selectively enhances learning rate (the strength of association between estimation error and subsequent update) of desirable feedback. IN-OT also increases participants' confidence in their estimates after receiving desirable but not undesirable feedback, and the OT effect on confidence updating upon desirable feedback mediates the effect of IN-OT on optimistic belief updating. Our findings reveal distinct functional roles of OT in updating the first-order estimation and second-order confidence judgment in response to desirable and undesirable feedback, suggesting a molecular substrate for optimistic belief updating. |
| URI | http://hdl.handle.net/20.500.11897/491574 |
| ISSN | 0027-8424 |
| DOI | 10.1073/pnas.1604285113 |
| Indexed | SCI(E) PubMed SSCI |
| Appears in Collections: | 心理与认知科学学院 行为与心理健康北京市重点实验室 |
