| Title | E. fischeriana Root Compound Dpo Activates Antiviral Innate Immunity |
| Authors | Chen, Jingxuan Du, Hongqiang Cui, Shuang Liu, Tong Yang, Guang Sun, Huaping Tao, Weiwei Jiang, Baoping Yu, Li You, Fuping |
| Affiliation | Peking Univ, Inst Syst Biomed, Sch Basic Med Sci, Dept Immunol,Hlth Sci Ctr, Beijing, Peoples R China. Peking Univ, Neurosci Res Inst, Key Lab Neurosci,Minist Educ, Natl Hlth & Family Planning Commiss Peoples Repub, Beijing, Peoples R China. Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing, Peoples R China. Jinan Univ, Sch Basic Med Sci, Dept Parasitol, Dept Publ Hlth & Prevent Med, Guangzhou, Guangdong, Peoples R China. Nanjing Univ Chinese Med, Jiangsu Hosp Tradit Chinese Med, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China. Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing, Jiangsu, Peoples R China. Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Pharm Coll, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing, Jiangsu, Peoples R China. Peking Univ, Inst Syst Biomed, Sch Basic Med Sci, Dept Immunol,Hlth Sci Ctr, Beijing, Peoples R China. You, FP (reprint author), Jinan Univ, Sch Basic Med Sci, Dept Parasitol, Dept Publ Hlth & Prevent Med, Guangzhou, Guangdong, Peoples R China. Yu, L (reprint author), Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Pharm Coll, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing, Jiangsu, Peoples R China. |
| Keywords | innate immunity viruses RLR signalling STING compound CYTOSOLIC DNA SENSOR EUPHORBIA-FISCHERIANA INTRACELLULAR DNA CELL ACTIVATION CUTTING EDGE KAPPA-B RIG-I ADAPTER DITERPENOIDS PROSTRATIN |
| Issue Date | 2017 |
| Publisher | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY |
| Citation | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2017, 7. |
| Abstract | E. fischeriana has long been used as a traditional Chinese medicine. Recent studies reported that some compounds of E. fischeriana exhibited antimicrobial and immune enhance activity. Innate immune system is essential for the immune surveillance of inner and outer threats, initial host defense responses and immune modulation. The role of natural drug compounds, including E. fischeriana, in innate immune regulation is largely unknown. Here we demonstrated that E. fischeriana compound Dpo is involved in antiviral signaling. The genome wide RNA-seq analysis revealed that the induction of ISGs by viral infection could be synergized by Dpo. Consistently, Dpo enhanced the antiviral immune responses and protected the mice from death during viral infection. Dpo however was not able to rescue STING deficient mice lethality caused by HSV-1 infection. The enhancement of ISG15 by Dpo was also impaired in STING, IRF3, IRF7, or ELF4 deficient cells, demonstrating that Dpo activates innate immune responses in a STING/IRFs/ELF4 dependent way. The STING/IRFs/ELF4 axis is therefore important for Dpo induced ISGs expression, and can be used by host to counteract infection. |
| URI | http://hdl.handle.net/20.500.11897/484592 |
| ISSN | 2235-2988 |
| DOI | 10.3389/fcimb.2017.00456 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
