| Title | Meta-analysis: diagnostic accuracy of antibody against peptidylarginine deiminase 4 by ELISA for rheumatoid arthritis |
| Authors | Ren, Jiaqi Sun, Lin Zhao, Jinxia |
| Affiliation | Peking Univ, Dept Rheumatol & Immunol, Hosp 3, 49 North Garden Rd, Beijing 100191, Peoples R China. |
| Keywords | Anti-PAD4 antibody Meta-analysis Rheumatoid arthritis UNAFFECTED 1ST-DEGREE RELATIVES SERUM IGG ANTIBODIES DISEASE SEVERITY TYPE-4 AUTOANTIBODIES ASSOCIATION PREVALENCE PAD4 CLASSIFICATION CITRULLINATION |
| Issue Date | 2017 |
| Publisher | CLINICAL RHEUMATOLOGY |
| Citation | CLINICAL RHEUMATOLOGY. 2017, 36(11), 2431-2438. |
| Abstract | The antibody against peptidylarginine deiminase (PAD) 4 is a biomarker that might be helpful in the diagnosis of rheumatoid arthritis (RA). We aim to estimate the diagnostic value of anti-PAD4 antibody for RA by meta-analysis. We searched PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for studies published in any languages in March 1, 2017 that evaluated the diagnostic accuracy of the anti-PAD4 antibody for the diagnosis of RA. The articles that detected the anti-PAD4 antibody by enzyme-linked immunosorbent assay (ELISA) and used healthy donors or patients without arthritis or arthralgia as controls were included for meta-analysis. The articles were assessed by Quality Assessment of Diagnostic Accuracy Studies tool. A bivariate mixed-effects model was used to summarize the diagnostic indexes from eight eligible studies. The pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-PAD4 antibody were 38% (95% CI 30.0-46.0%), 96% (95% CI 93.0-98.0%), 8.96 (95% CI 5.00-16.05), and 0.65 (95% CI 0.57-0.74), respectively. The summary diagnostic odds ratios were 13.74 (95% CI 7.23-26.09), and the area under the summary receiver operator characteristic curve was 86% (95% CI 83-89%). Anti-PAD4 antibody detected by ELISA shows a high value in the diagnosis of RA with high specificity, but relatively low sensitivity. |
| URI | http://hdl.handle.net/20.500.11897/484578 |
| ISSN | 0770-3198 |
| DOI | 10.1007/s10067-017-3809-0 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
