| Title | Roles of RNA methylation by means of N-6-methyladenosine (m(6)A) in human cancers |
| Authors | Wang, Siwei Sun, Chunxiao Li, Jianhua Zhang, Erbao Ma, Zhifei Xu, Weizhang Li, Hong Qiu, Mantang Xu, Youtao Xia, Wenjia Xu, Lin Yin, Rong |
| Affiliation | Jiangsu Canc Hosp, Dept Thorac Surg, Nanjing 210009, Jiangsu, Peoples R China. Jiangsu Inst Canc Res, Nanjing 210009, Jiangsu, Peoples R China. Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Key Lab Mol & Translat Canc Res, Nanjing 210009, Jiangsu, Peoples R China. Nanjing Med Univ, Clin Coll 4, Nanjing 210000, Jiangsu, Peoples R China. Nanjing Med Univ, Affiliated Hosp 1, Nanjing 210000, Jiangsu, Peoples R China. Taizhou Peoples Hosp, Dept Pharm, Taizhou 225300, Peoples R China. Nanjing Med Univ, Sch Publ Hlth, Collaborat Innovat Ctr Canc Personalized Med,Dept, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210000, Jiangsu, Peoples R China. Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing 100044, Peoples R China. Baiziting 42, Nanjing 210009, Jiangsu, Peoples R China. |
| Keywords | RNA methylation N-6-methyladenosine m(6)A Human cancers Cancer therapy ACUTE MYELOID-LEUKEMIA S-ADENOSYLHOMOCYSTEINE HYDROLASE GENE-EXPRESSION REGULATION OBESITY-ASSOCIATED FTO CELL MESSENGER-RNA DEMETHYLASE ALKBH5 NUCLEAR-RNA BREAST-CANCER N-6-ADENOSINE METHYLTRANSFERASE HEPATOCELLULAR-CARCINOMA |
| Issue Date | 2017 |
| Publisher | CANCER LETTERS |
| Citation | CANCER LETTERS. 2017, 408, 112-120. |
| Abstract | Reversible methylation by means of N6-methyladenosine (m(6)A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m(6)A "writers" and can be reversed by proteins that are m(6)A "erasers" (i.e., demethylases). Some other proteins serving as "readers" can recognize m(6)A-containing mRNA and regulate downstream molecular mechanisms accordingly. Although m(6)A bases in RNA perform critical functions in important biological processes, their roles in cancer biology and cancer stem cells remain largely unknown. In this review, we focus on the m(6)A-associated mechanisms and modification landscapes in several major malignant tumors. Global and detailed analyses were both conducted on relevant high-throughput sequencing data. Possible interventions against m(6)A demethylases are also explored in this review, which may be advantageous for the treatment of m(6)A related cancers. (C) 2017 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/484549 |
| ISSN | 0304-3835 |
| DOI | 10.1016/j.canlet.2017.08.030 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
