| Title | Absorption kinetics of flurbiprofen axetil microspheres in cerebrospinal fluid: A pilot study |
| Authors | Zhang, Hong Gu, Jian Feng, Yi An, Haiyan |
| Affiliation | Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100044, Peoples R China. Peking Univ, Peoples Hosp, Dept Pharm, Beijing, Peoples R China. |
| Keywords | flurbiprofen cerebro-spinal fluid concentration blood concentration analgesia CYCLOOXYGENASE-2 INHIBITORS PAIN MANAGEMENT INJECTION PROPOFOL SAFETY PLASMA |
| Issue Date | 2017 |
| Publisher | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2017, 55(11), 875-880. |
| Abstract | Objective: The purpose of this study is to investigate the absorption dynamics of flurbiprofen axetil in cerebrospinal fluid. Materials and methods: We analyzed the concentrations of flurbiprofen in peripheral venous blood and cerebrospinal fluid (CSF) to explore the absorption dynamics of flurbiprofen axetil loaded in lipid microspheres in CSF. 72 adult patients who planned to undergo selective operations under spinal anesthesia or combined spinal-epidural anesthesia were intravenously injected with flurbiprofen axetil (1 mg/kg) and randomly divided into nine groups according to the sampling time after administration: 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25), 30 (T30), 35 (T35), 40 (T40), and 45 minutes (T45). The CSF and venous blood samples collected from patients were analyzed by reverse-phase high-performance liquid chromatography to determine the concentrations of flurbiprofen. Results: With the exception of 3 CSF samples in T5 and 4 CSF samples in T10, flurbiprofen was detected in all CSF and blood specimens. Significant differences between the CSF concentrations and CSF/plasma drug concentration ratios were observed among the nine time points (p < 0.001), whereas no significant difference in plasma concentration was found (p > 0.05). Conclusions: The findings suggest that lipid microspheres loaded with flurbiprofen can penetrate through the blood-brain barrier into CSF after intravenous injection. The fact that the flurbiprofen concentration rose continuously for 45 minutes after injection indicates that flurbiprofen-loaded lipid microspheres may exert analgesic action via the central nervous system. |
| URI | http://hdl.handle.net/20.500.11897/484538 |
| ISSN | 0946-1965 |
| DOI | 10.5414/CP203092 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
