| Title | Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012) |
| Authors | Su, Yun-Ai Yan, Feng Li, Qian Xiang, Yu-Tao Shu, Liang Yu, Xin Ning, Yu-Ping Zhang, Ke-Rang Li, Tao Mei, Qi-Yi Li, Ke-Qing Si, Tian-Mei |
| Affiliation | Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China. Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China. Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China. Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China. Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China. Capital Med Univ, Beijing Inst Brain Disorders, Ctr Depress, Beijing, Peoples R China. Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China. Univ Macau, Fac Hlth Sci, Unit Psychiat, Macau, Peoples R China. Psychiat Hosp, Guangzhou, Guangdong, Peoples R China. Shanxi Med Univ, Hosp 1, Xian, Shaanxi, Peoples R China. Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China. Suzhou Guangji Hosp, Suzhou, Peoples R China. Hebei Mental Hlth Ctr, Baoding, Hebei, Peoples R China. Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China. Si, TM (reprint author), Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China. Si, TM (reprint author), Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China. |
| Keywords | Schizophrenia Prescription patterns Anticholinergic medication Extrapyramidal symptoms OF-LIFE FINDINGS ATYPICAL ANTIPSYCHOTICS TREATMENT SATISFACTION DRUGS ASSOCIATION |
| Issue Date | 2017 |
| Publisher | PSYCHIATRY RESEARCH |
| Citation | PSYCHIATRY RESEARCH. 2017, 257, 132-136. |
| Abstract | Our previous study demonstrated that there have been changes in the patterns of prescription antipsychotic use in China over the period from 2002 to 2012. The aim of this study was to evaluate whether time trends were present for the prescription of anticholinergic medications (ACMs) during the observation period. A total of 14,013 patients with schizophrenia treated in 45 psychiatric hospitals/centers nationwide were surveyed in 2002, 2006 and 2012. Basic socio-demographic and clinical characteristics and the prescription of psychotropic drugs were recorded using a standardized protocol and data collection procedure. The frequency of ACM prescription was 25.9% in the whole sample (29.5%, 21.6%, and 27.4% in 2002, 2006 and 2012, respectively). In addition, different temporal trends were observed across age groups. Multiple logistic regression analysis of the entire sample showed that ACM prescriptions were predicted by females, outpatients, patients receiving high doses of antipsychotic medication, select study years, benzodiazepine users, patients displaying extrapyramidal side effects, as well as antipsychotic prescription patterns. Although there was more widespread use of second generation antipsychotics over the past decade, the frequency of ACM use only slightly decreased. How to use ACM appropriately is still a therapeutic issue that needs to foster evidence-based prescription practice. |
| URI | http://hdl.handle.net/20.500.11897/480255 |
| ISSN | 0165-1781 |
| DOI | 10.1016/j.psychres.2017.07.038 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第六医院 北京回龙观医院 |
