| Title | Reproductive factors are associated with oesophageal cancer risk: results from a meta-analysis of observational studies |
| Authors | Zhu, Yuhui Yue, Dahai Yuan, Beibei Zhu, Lianhua Lu, Ming |
| Affiliation | Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Jinan, Peoples R China. Shandong Univ, Clin Epidemiol Unit, Qilu Hosp, Jinan 250012, Peoples R China. Deqing Cty Ctr Dis Control & Prevent, Huzhou, Zhejiang, Peoples R China. Peking Univ, China Ctr Hlth Dev Studies, Beijing, Peoples R China. |
| Keywords | meta-analysis oesophageal cancer reproductive factors SQUAMOUS-CELL CARCINOMA ESTROGEN-RECEPTOR-ALPHA HORMONAL FACTORS BREAST-CANCER POSTMENOPAUSAL WOMEN BARRETTS-ESOPHAGUS GASTRIC-CANCER OVARIAN-CANCER SEX-HORMONES COLON-CANCER |
| Issue Date | 2017 |
| Publisher | EUROPEAN JOURNAL OF CANCER PREVENTION |
| Citation | EUROPEAN JOURNAL OF CANCER PREVENTION.2017,26(1),1-9. |
| Abstract | To further evaluate the association between reproductive events and the development of oesophageal cancer, we searched relevant studies using electronic databases (PubMed, ISI Web of Science). Study-specific relative risks with corresponding 95% confidence intervals (CI) in all analyses were used and multiple summary relative risk (SRR) estimates were calculated. We carried out subgroup analyses and used meta-regression techniques to explore potential sources of heterogeneity. Sensitivity analysis was carried out to identify whether pooled results were influenced by individual studies and publication bias was assessed by Begg's funnel plots and the Egger regression asymmetry test. Fourteen studies were eligible for inclusion in the meta-analysis, summarizing a total of 3816 oesophageal cancer cases. We found that age at menopause (SRR=0.70; 95% CI: 0.51-0.95) and hormone replacement therapy (SRR=0.67; 95% CI: 0.56-0.81) had an association with a decreased risk of oesophageal cancer. A similar result was obtained for parity (SRR=0.79; 95% CI: 0.71-0.89) and ever breastfeeding (SRR=0.65; 95% CI: 0.43-0.97). In contrast, postmenopausal status was associated with increased risk (SRR=1.65; 95% CI: 1.28-2.14). No statistically significant link was found with other exposures. Our meta-analysis supports the substantial influence of reproductive factors, which could be causally linked to oesophageal cancer. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/476516 |
| ISSN | 0959-8278 |
| DOI | 10.1097/CEJ.0000000000000234 |
| Indexed | SCI(E) |
| Appears in Collections: | 国家发展研究院 |
