| Title | Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes |
| Authors | Wang, Anxin Yang, Yuling Su, Zhaoping Yue, Wei Hao, Hongjun Ren, Lijie Wang, Yongjun Cao, Yibin Wang, Yilong |
| Affiliation | Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China. China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China. Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China. Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China. Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China. Tangshan Gongren Hosp, Dept Neurol, Tangshan, Peoples R China. Weifang Med Univ, Acad Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Weifang, Peoples R China. Tianjin Med Univ, Hosp 2, Dept Neurol, Tianjin, Peoples R China. Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China. Peking Univ, Hosp 1, Dept Neurol, Beijing, Peoples R China. Shenzhen Second Peoples Hosp, Dept Neurol, Shenzhen, Peoples R China. 6 Tiantanxili, Beijing 100050, Peoples R China. Cao, YB (reprint author), 27 Wenhua Rd, Tangshan City 063000, Hebei Province, Peoples R China. |
| Keywords | atherosclerosis lipoproteins oxidized low density lipoprotein prognosis stroke ENDOTHELIAL PROGENITOR CELLS ACUTE ISCHEMIC-STROKE RISK-FACTOR GLOBAL BURDEN DISEASE PLAQUE LDL |
| Issue Date | 2017 |
| Publisher | STROKE |
| Citation | STROKE.2017,48(1),91-+. |
| Abstract | Background and Purpose-The association between oxidized low-density lipoprotein (oxLDL) and the long-term prognosis of stroke is unclear. The aim of this study is to investigate whether oxLDL levels contribute to the prognosis of stroke and stroke subtypes. Methods-All patients with ischemic stroke were recruited from the SOS-Stroke (Study of Oxidative Stress in Patients With Acute Ischemic Stroke) and classified into 5 different subtypes, according to the TOAST criteria (Trial of Org 10172 in Acute Stroke Treatment). We measured oxLDL levels and followed up with patients at 1 year after stroke onset. We analyzed the association between oxLDL and the clinical outcomes of death and poor functional outcome (modified Rankin Scale score of 3-6) of stroke and different stroke subtypes. Results-Among the 3688 patients included in this study, 293 (7.94%) were deceased at the 1-year follow-up and 1020 (27.66%) had a poor functional outcome. Patients in the highest oxLDL quartile had a higher risk of 1-year stroke mortality (hazard ratio, 1.61; 95% confidence interval, 1.10-2.33; P<0.001) and a poor functional outcome (odds ratio, 1.48; 95% confidence interval, 1.15-1.89; P<0.001) compared with the lowest oxLDL quartile. In the subgroup analyses, oxLDL was only significantly associated with death and poor functional outcome in the large-artery atherosclerosis subgroup (P<0.05) and small-artery occlusion subgroup (P<0.05). Conclusions-High levels of oxLDL were associated with the high risk of death and poor functional outcome within 1 year after stroke onset, especially in large-artery atherosclerosis and small-artery occlusion stroke subtypes. |
| URI | http://hdl.handle.net/20.500.11897/476484 |
| ISSN | 0039-2499 |
| DOI | 10.1161/STROKEAHA.116.014816 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
