| Title | An enyne cycloisomerization/[5+1] reaction sequence to synthesize tetrahydroisoquinolinones from enyne-enes and CO |
| Authors | Zhuang, Zhe Li, Chen-Long Xiang, Yu Wang, Yu-Hao Yu, Zhi-Xiang |
| Affiliation | Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China. |
| Keywords | CATALYZED ASYMMETRIC CYCLOISOMERIZATION NITROGEN-BRIDGED 1,6-ENYNES 5+1 CYCLOADDITION ENANTIOSELECTIVE CYCLOISOMERIZATION ISOQUINOLINE ALKALOIDS STEREOSELECTIVE DOMINO NATURAL-PRODUCTS GOLD CATALYSIS COMPLEXES CYCLOPROPYL |
| Issue Date | 2017 |
| Publisher | CHEMICAL COMMUNICATIONS |
| Citation | CHEMICAL COMMUNICATIONS.2017,53(13),2158-2161. |
| Abstract | An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. The first step is a gold(I)-catalyzed enyne cycloisomerization, generating six-membered- ring-fused vinylcyclopropanes. The second step is a rhodium(I)catalyzed [5+1] reaction of vinylcyclopropanes with CO. This two-step reaction could also be carried out in one-pot without isolating the cycloisomerization product generated from the first step of this sequence. |
| URI | http://hdl.handle.net/20.500.11897/476158 |
| ISSN | 1359-7345 |
| DOI | 10.1039/c6cc09925d |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
