| Title | Tandem repeats of aggrecan gene and susceptibility of disc degeneration diseases: a case-control study and meta-analysis |
| Authors | Wu, Xiaolin Li, Haiyan Wang, Ronghuan Yue, Bin Yan, Jun Yang, Nailong Sheng, Zhaofu Wang, Guihua Chen, Bohua |
| Affiliation | Qingdao Univ, Affiliated Hosp, Dept Orthopaed, Qingdao 100054, Peoples R China. De Zhou Municiple Hosp, Dept Orthopaed, De Zhou, Peoples R China. De Zhou Municiple Hosp, Dept Oncol, De Zhou, Peoples R China. Peking Univ, Coll Pharm, Beijing, Peoples R China. |
| Keywords | Intervertebral disc degeneration case-control study meta-analysis aggrecan gene polymorphisms GENOME-WIDE ASSOCIATION INTERVERTEBRAL DISC VARIABLE NUMBER POLYMORPHISM REPLICATION ALLELES TWINS BIAS |
| Issue Date | 2017 |
| Publisher | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2017,10(4),5892-5902. |
| Abstract | Several studies have examined the association between aggrecan gene variable number of tandem repeats (VNTR) polymorphism and risk of intervertebral disc degeneration (IDD). However, the results are still controversial. We recruited 98 IDD patients and 94 controls from May 2011 to August 2015. All the subjects were genotyped using the PCR-based invader assay. The differences of allele distributions between IDD patients and controls were investigated in case-control study. A systematic search of all relevant studies was conducted. The observational studies that were related to an association between aggrecan VNTR polymorphism and IDD were identified. The association between aggrecan VNTR polymorphism and risk of IDD was assessed by meta-analysis. The case-control study showed that aggrecan VNTR polymorphism was associated with the susceptibility of IDD in a Chinese population (P < 0.05). Furthermore, other eight previously reported studies were included to perform meta-analysis. The meta-analysis showed that aggrecan VNTR polymorphism was associated with risk of IDD in Asian (OR = 1.50, 95% CI = 1.17-1.93) but not in Caucasians (OR = 1.35, 95% CI = 0.84-2.18). The present study suggested that aggrecan VNTR polymorphism with shorter allele may be associated with the increased risk of IDD in Chinese population. The further meta-analysis provides additional evidence supporting the above result in Asian. However, such association may not be statistically significant in Caucasians. |
| URI | http://hdl.handle.net/20.500.11897/476060 |
| ISSN | 1940-5901 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 |
