| Title | Clinical features of patients with pancreatic neuroendocrine neoplasms: a retrospective analysis of 61 cases in a cancer center |
| Authors | Zhang, Panpan Lu, Ming Wang, Xicheng Shen, Lin Li, Jian Zhou, Jun Zhang, Xiaotian Peng, Zhi Cao, Yanshuo Yang, Zuyao Li, Jie |
| Affiliation | Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept GI Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing, Peoples R China. Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. |
| Keywords | Pancreatic neuroendocrine neoplasm diagnosis treatment serum CgA CHROMOGRANIN-A PRIMARY TUMOR SURVIVAL CHEMOTHERAPY CARCINOMAS GUIDELINES MANAGEMENT PREDICTOR RESECTION THERAPY |
| Issue Date | 2017 |
| Publisher | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2017,10(3),4897-4904. |
| Abstract | Objective: To assess the clinicopathological features of patients with pancreatic neuroendocrine neoplasms (pNENs) in relation with clinical outcomes. Methods: A total of 61 patients with pNENs were enrolled in this study. Patients' characteristics, treatment procedures, and clinical follow-up were retrospectively analyzed. Results: Among the 61 patients, 29 patients (47.5%) were men and 32 patients (52.5%) were women. 6 patients (9.8%) had functional pNENs and presented with diarrhea, flushing, sweating, palpitations or glucose abnormalities. At diagnosis, 31.1% (19/61) had a localized disease, 6.6% (4/61) presented with regional spread including lymph node metastases and/or extrapancreatic organ invasions, and 62.3% (38/61) had distant metastases. Liver was the most common site of metastasis. 58 cases were recorded with detailed pathological information, among which 42 patients (72.4%) were diagnosed as NET G1/G2, 16 patients (27.6%) were diagnosed as NEC G3. The chromogranin A (CgA) levels were elevated in the serum of patients with liver metastasis, unresectable tumors or a Ki-67 proliferative index >= 20%. The univariate analysis suggested that the WHO classification, stage, occurrence of liver metastasis and operative approaches were closely related to the prognosis of pNENs; while sex, age, tumor size and functional status were not. Conclusion: The pNENs are a heterogeneous group of neoplasms with diverse clinical manifestations and prognosis. Serum CgA is an indicator of tumor burden and proliferation. The WHO classification, stage, liver metastasis and operative approaches might closely relate to the prognosis of pNENs. |
| URI | http://hdl.handle.net/20.500.11897/476057 |
| ISSN | 1940-5901 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
