| Title | Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy |
| Authors | Deng, Guanjun Zhu, Ting Zhou, Lihua Zhang, Jingnan Li, Sanpeng Sun, Zhihong Lai, Jiazheng Meng, Xiaoqing Li, Wenjun Zhang, Pengfei Wu, Yayun Jiang, Tao Ni, Dapeng Yan, Weiqiang Zheng, Mingbin Gong, Ping Cai, Lintao |
| Affiliation | Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China. Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China. Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518037, Peoples R China. Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China. Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China. Peking Univ, Shenzhen Hosp, Dept Radiol, Shenzhen 518036, Peoples R China. Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China. Gong, P (reprint author), Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China. Gong, P (reprint author), Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China. |
| Keywords | ANTICANCER EFFICACY PROSTATE-CANCER IN-VIVO MESOTHELIOMA HYPERTHERMIA ANTIOXIDANT XENOGRAFTS INDUCTION CISPLATIN APOPTOSIS |
| Issue Date | 2017 |
| Publisher | RSC ADVANCES |
| Citation | RSC ADVANCES.2017,7(49),30717-30724. |
| Abstract | A combination of chemotherapy and photothermal treatment has already become a promising strategy for cancer treatment. Hence, it is highly desirable to develop a safe and effective delivery system. In the present study, we have developed bovine serum albumin-loaded nano-selenium (SeNPs)/indocyanine green (ICG) nanoparticles (BSINPs) that were generated by a programmed assembly method. They could simultaneously deliver SeNPs (a chemotherapeutic agent) and ICG (a photothermal agent) to tumor regions for combined chemo-photothermal therapy. BSINPs presented good monodispersity, a suitable size, fluorescence stability, and characteristic spectral features in comparison with free ICG. Moreover, the BSINPs displayed a longer retention time in tumors and a higher temperature response under laser irradiation. In addition, the process of subcellular location in vitro and the distribution of BSINPs in vivo could be monitored. The combined therapy offered by the BSINPs with laser irradiation synergistically induced the death of U87L glioma cells, and completely inhibited U87L tumor growth in vivo compared with chemo or photothermal therapy alone. Outstandingly, no tumor recurrence or treatment-induced toxicity was observed after a single-dose of BSINPs with laser irradiation. The results indicate that the well-defined BSINPs are highly desirable for cancer treatment with chemo-photothermal therapy. |
| URI | http://hdl.handle.net/20.500.11897/475965 |
| ISSN | 2046-2069 |
| DOI | 10.1039/c7ra02384g |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
