| Title | From Micro to Macro: The Hierarchical Design in a Micropatterned Scaffold for Cell Assembling and Transplantation |
| Authors | Wang, Kai Wang, Xi Han, Chengsheng Hou, Wenda Wang, Jinyang Chen, Liangyi Luo, Ying |
| Affiliation | Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China. Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China. |
| Keywords | MESENCHYMAL STEM-CELLS EXTRAHEPATIC ISLET TRANSPLANTATION PANCREATIC BETA-CELLS IN-VITRO STROMAL/STEM CELLS EDMONTON PROTOCOL POLYMER SCAFFOLDS DIABETIC MICE FOLLOW-UP MICROENVIRONMENT |
| Issue Date | 2017 |
| Publisher | ADVANCED MATERIALS |
| Citation | ADVANCED MATERIALS.2017,29(2). |
| Abstract | A microwell-patterned membranous scaffold that integrates nano- and micro-scale topographical characteristics based on polyurethane is fabricated for transplanting syngeneic islets and allogeneic mesenchymal stem cells into diabetic rodents. The scaffold effectively allows for assembling of single cells/microtissues, enables the transplantation of cells with spatial control, and improves the transplant's engraftment efficacy in vivo for treating diabetes. |
| URI | http://hdl.handle.net/20.500.11897/475721 |
| ISSN | 0935-9648 |
| DOI | 10.1002/adma.201604600 |
| Indexed | SCI(E) |
| Appears in Collections: | 工学院 分子医学研究所 |
