| Title | Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids |
| Authors | Zhao, Hui Jiang, Yanhong Tian, Yuan Yang, Dan Qin, Xuan Li, Zigang |
| Affiliation | Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen 518055, Peoples R China. Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 611756, Peoples R China. |
| Keywords | CYCLIC-PEPTIDES STAPLED PEPTIDES PRINCIPLES INHIBITORS |
| Issue Date | 2017 |
| Publisher | ORGANIC & BIOMOLECULAR CHEMISTRY |
| Citation | ORGANIC & BIOMOLECULAR CHEMISTRY.2017,15(2),459-464. |
| Abstract | Cell penetration and nucleus translocation efficiency are important for the cellular activities of peptide therapeutics. For helical peptides stabilized by N-terminal crosslinked aspartic acid, correlations between their penetration efficiency/nucleus translocation and physicochemical properties were studied. An increase in hydrophobicity and isoelectric point will promote cellular uptake and nucleus translocation of stabilized helices. |
| URI | http://hdl.handle.net/20.500.11897/475699 |
| ISSN | 1477-0520 |
| DOI | 10.1039/c6ob02501c |
| Indexed | SCI(E) |
| Appears in Collections: | 化学生物学与生物技术学院 |
