| Title | Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions |
| Authors | Chen, Yao Huang, Xiao-Jun Liu, Kai-Yan Chen, Huan Chen, Yu-Hong Zhang, Xiao-Hui Wang, Yu Wang, Feng-Rong Han, Wei Wang, Jing-Zhi Yan, Chen-Hua Xu, Lan-Ping |
| Affiliation | Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China. |
| Keywords | C-reactive protein engraftment syndrome graft-versus-host disease aploidentical stem cell transplantation STEM-CELL TRANSPLANTATION VERSUS-HOST-DISEASE CORD-BLOOD TRANSPLANTATION BONE-MARROW-TRANSPLANTATION ENGRAFTMENT SYNDROME HEMATOLOGICAL MALIGNANCIES NONRELAPSE MORTALITY MAJOR COMPLICATIONS HEMATOPOIETIC SCT SERUM-LEVELS |
| Issue Date | 2017 |
| Publisher | BIOMARKERS IN MEDICINE |
| Citation | BIOMARKERS IN MEDICINE.2017,11(2),117-124. |
| Abstract | Aim: The purpose of this study was to determine whether C-reactive protein (CRP) in the first 1-3 days post-transplant could predict allogeneic immune reactions, including engraftment syndrome or acute graft-versus-host disease (GVHD), in pediatric haploidentical stem cell transplantation. Patients & methods: The study population comprised 175 consecutive pediatric patients. Receiver operating characteristic analysis was performed to identify the cut-off CRP value. Results: The high-CRP group (>= 20.1 mg/ l) was associated with an increased occurrence of engraftment syndrome (hazard ratio [HR] = 2.046; p = 0.008), II-IV acute GVHD (HR = 2.203; p = 0.001) and severe GVHD (HR = 6.371; p = 0.004). Conclusion: Our data suggest that higher CRP during the first 1-3 days post-transplant could be a predictor of allogeneic immune reactions. |
| URI | http://hdl.handle.net/20.500.11897/475465 |
| ISSN | 1752-0363 |
| DOI | 10.2217/bmm-2016-0244 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
